Advances in clinical detection methods and nanomaterials for autoimmune liver diseases

Abstract

Autoimmune liver disease (AILD) is a kind of chronic liver disease, due to the autoimmune tolerance of the liver break-down, as well as the imbalance of immune cell numbers and functions led to persistent inflammatory damage of the liver. With the rapid development of diagnoses and treatments, the proportion of liver diseases has changed significantly. Autoimmune liver diseases have gradually become one of the focuses of scholars worldwide. The specificity and sensitivity of diagnostic and prognostic evaluation methods of AILD have always been social concerns of the researchers owing to the variety of etiology, incompletely understood pathogenesis and different clinical phenotypes. This article reviews the current research status and summarizes the research advances and nanomaterials of the diagnosis and prognosis evaluation methods of AILDs.