{"title":"Membrane fusion boosting drug transmembrane delivery","authors":"Xing Gao, En Ren, Gang Liu","doi":"10.1016/j.smaim.2022.01.009","DOIUrl":null,"url":null,"abstract":"<div><p>Benefiting from fusion element (peptides or proteins) anchoring, several biological membrane vesicles or synthetic liposomes have great potency to fuse with the target cell membrane <em>via</em> virus-mimetic behavior. When this process happens, the encapsulated cargos can be released directly into the cytoplasm together with membrane component (protein receptor, channel proteins, chemical receptors, antibodies) transfer, a process that facilitates cellular/molecular diagnosis and therapy.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183422000096/pdfft?md5=1bdf770af6b9b1acbe7c0169dbc11228&pid=1-s2.0-S2590183422000096-main.pdf","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Smart Materials in Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590183422000096","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 3
Abstract
Benefiting from fusion element (peptides or proteins) anchoring, several biological membrane vesicles or synthetic liposomes have great potency to fuse with the target cell membrane via virus-mimetic behavior. When this process happens, the encapsulated cargos can be released directly into the cytoplasm together with membrane component (protein receptor, channel proteins, chemical receptors, antibodies) transfer, a process that facilitates cellular/molecular diagnosis and therapy.
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