miRNAs as biomarkers of autism spectrum disorder: a systematic review and meta-analysis.

IF 6 2区 医学 Q1 PEDIATRICS European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2023-02-03 DOI:10.1007/s00787-023-02138-3
Nathalia Garrido-Torres, Karem Guzmán-Torres, Susana García-Cerro, Gladys Pinilla Bermúdez, Claudia Cruz-Baquero, Hansel Ochoa, Diego García-González, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla
{"title":"miRNAs as biomarkers of autism spectrum disorder: a systematic review and meta-analysis.","authors":"Nathalia Garrido-Torres, Karem Guzmán-Torres, Susana García-Cerro, Gladys Pinilla Bermúdez, Claudia Cruz-Baquero, Hansel Ochoa, Diego García-González, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla","doi":"10.1007/s00787-023-02138-3","DOIUrl":null,"url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex clinical manifestations that arise between 18 and 36 months of age. Social interaction deficiencies, a restricted range of interests, and repetitive stereotyped behaviors are characteristics which are sometimes difficult to detect early. Several studies show that microRNAs (miRs/miRNAs) are strongly implicated in the development of the disorder and affect the expression of genes related to different neurological pathways involved in ASD. The present systematic review and meta-analysis addresses the current status of miRNA studies in different body fluids and the most frequently dysregulated miRNAs in patients with ASD. We used a combined approach to summarize miRNA fold changes in different studies using the mean values. In addition, we summarized p values for differential miRNA expression using the Fisher method. Our literature search yielded a total of 133 relevant articles, 27 of which were selected for qualitative analysis based on the inclusion and exclusion criteria, and 16 studies evaluating miRNAs whose data were completely reported were ultimately included in the meta-analysis. The most frequently dysregulated miRNAs across the analyzed studies were miR-451a, miR-144-3p, miR-23b, miR-106b, miR150-5p, miR320a, miR92a-2-5p, and miR486-3p. Among the most dysregulated miRNAs in individuals with ASD, miR-451a is the most relevant to clinical practice and is associated with impaired social interaction. Other miRNAs, including miR19a-3p, miR-494, miR-142-3p, miR-3687, and miR-27a-3p, are differentially expressed in various tissues and body fluids of patients with ASD. Therefore, all these miRNAs can be considered candidates for ASD biomarkers. Saliva may be the optimal biological fluid for miRNA measurements, because it is easy to collect from children compared to other biological fluids.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424746/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Child & Adolescent Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00787-023-02138-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/2/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex clinical manifestations that arise between 18 and 36 months of age. Social interaction deficiencies, a restricted range of interests, and repetitive stereotyped behaviors are characteristics which are sometimes difficult to detect early. Several studies show that microRNAs (miRs/miRNAs) are strongly implicated in the development of the disorder and affect the expression of genes related to different neurological pathways involved in ASD. The present systematic review and meta-analysis addresses the current status of miRNA studies in different body fluids and the most frequently dysregulated miRNAs in patients with ASD. We used a combined approach to summarize miRNA fold changes in different studies using the mean values. In addition, we summarized p values for differential miRNA expression using the Fisher method. Our literature search yielded a total of 133 relevant articles, 27 of which were selected for qualitative analysis based on the inclusion and exclusion criteria, and 16 studies evaluating miRNAs whose data were completely reported were ultimately included in the meta-analysis. The most frequently dysregulated miRNAs across the analyzed studies were miR-451a, miR-144-3p, miR-23b, miR-106b, miR150-5p, miR320a, miR92a-2-5p, and miR486-3p. Among the most dysregulated miRNAs in individuals with ASD, miR-451a is the most relevant to clinical practice and is associated with impaired social interaction. Other miRNAs, including miR19a-3p, miR-494, miR-142-3p, miR-3687, and miR-27a-3p, are differentially expressed in various tissues and body fluids of patients with ASD. Therefore, all these miRNAs can be considered candidates for ASD biomarkers. Saliva may be the optimal biological fluid for miRNA measurements, because it is easy to collect from children compared to other biological fluids.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
作为自闭症谱系障碍生物标志物的 miRNAs:系统综述与荟萃分析。
自闭症谱系障碍(ASD)是一种神经发育障碍,临床表现复杂,发病年龄在 18 到 36 个月之间。自闭症谱系障碍(ASD)是一种神经发育障碍,临床表现复杂,多发生在 18 到 36 个月大的儿童身上。自闭症谱系障碍的特征包括社交互动障碍、兴趣狭窄和重复刻板行为,这些特征有时很难在早期发现。多项研究表明,微小核糖核酸(miRs/miRNAs)与该疾病的发展密切相关,并影响与 ASD 所涉及的不同神经通路相关的基因的表达。本系统综述和荟萃分析探讨了不同体液中 miRNA 的研究现状,以及 ASD 患者中最常见的失调 miRNA。我们采用了一种综合方法,利用平均值总结了不同研究中 miRNA 的折叠变化。此外,我们还采用费雪法总结了不同 miRNA 表达的 p 值。通过文献检索,我们共获得了 133 篇相关文章,根据纳入和排除标准,我们选择了其中的 27 篇文章进行定性分析,最终有 16 项评估 miRNA 的研究被纳入了荟萃分析,这些研究的数据均已完整报告。在所分析的研究中,最常见的失调 miRNA 是 miR-451a、miR-144-3p、miR-23b、miR-106b、miR150-5p、miR320a、miR92a-2-5p 和 miR486-3p。在 ASD 患者体内失调最严重的 miRNAs 中,miR-451a 与临床实践最为相关,它与社会交往能力受损有关。其他 miRNA,包括 miR19a-3p、miR-494、miR-142-3p、miR-3687 和 miR-27a-3p,在 ASD 患者的不同组织和体液中都有不同程度的表达。因此,所有这些 miRNA 都可被视为 ASD 生物标志物的候选者。唾液可能是测量 miRNA 的最佳生物液体,因为与其他生物液体相比,唾液易于从儿童身上收集。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
12.80
自引率
4.70%
发文量
186
审稿时长
6-12 weeks
期刊介绍: European Child and Adolescent Psychiatry is Europe''s only peer-reviewed journal entirely devoted to child and adolescent psychiatry. It aims to further a broad understanding of psychopathology in children and adolescents. Empirical research is its foundation, and clinical relevance is its hallmark. European Child and Adolescent Psychiatry welcomes in particular papers covering neuropsychiatry, cognitive neuroscience, genetics, neuroimaging, pharmacology, and related fields of interest. Contributions are encouraged from all around the world.
期刊最新文献
Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study. Early psychopathology: a persistently misunderstood and overlooked issue? Mediation of DNA methylation (cg04622888 and cg05037505) in the association between childhood maltreatment and non-suicidal self-injury in early adolescents. Adult mental health outcomes of adolescent depression and co-occurring alcohol use disorder: a longitudinal cohort study. Associations between academic achievement and internalizing disorders in Swedish students aged 16 years between 1990 and 2018.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1