Optical, microstructural, and magnetic hyperthermia properties of green-synthesized Fe3O4/carbon dots nanocomposites utilizing Moringa oleifera extract and watermelon rinds

Abstract

Cancer therapy with targeted-localized heating is one of the breakthroughs in the biomedical field. The incorporation of magnetic nanoparticles and fluorescent nanoparticles was one of the crucial issues for magnetic hyperthermia applications. This research investigates the magnetic hyperthermia properties of green-synthesized Fe₃O₄/CDs. Fe₃O₄ nanoparticles were synthesized using the coprecipitation method with Moringa oleifera leaf extract as a reducing agent and stabilizer. In contrast, CDs were synthesized using a hydrothermal method with watermelon rind waste as a carbon source. X-ray diffraction analysis confirmed the presence of cubic inverse spinel and a reduction in crystallite size with increasing CDs concentration. Transmission electron microscopy revealed particle size distributions of 9.7 nm for Fe₃O₄ and 7.5 nm for Fe₃O₄/CDs. Scanning electron microscopy showed that CDs were distributed on the surface of Fe₃O₄. The detection of characteristic FeO, CC, CO, and CO-C bonds indicated the presence of CDs on the surface of Fe₃O₄. Ultraviolet-visible spectroscopy spectra absorption peaks at 282 nm for CDs and 193 nm for Fe₃O₄. Photoluminescence spectra indicated shifts from 509 to 505 nm in excitation wavelength for both CDs and Fe₃O₄/CDs, situated within the green region of visible light. The vibrating sample magnetometer revealed that the nanocomposites displayed characteristics of soft ferromagnetic materials. Furthermore, the specific absorption rate (SAR) value of Fe₃O₄/CDs was found to be dependent on magnetization. The SAR value of Fe₃O₄/CDs decreased as the concentration of CDs increased, and the frequency and strength of the AMF increased. Therefore, these results can promote Fe₃O₄/CDs nanocomposites as a promising candidate for magnetic hyperthermia applications.