Modulatory role of prolactin in type 1 diabetes.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-03-01 DOI:10.1515/hmbci-2022-0008

Edgar Ramos-Martínez, Ivan Ramos-Martínez, Jorge Valencia, Juan Carlos Ramos-Martínez, Luis Hernández-Zimbrón, Anaiza Rico-Luna, Eduardo Pérez-Campos, Laura Pérez-Campos Mayoral, Marco Cerbón

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Abstract

Objectives: Patients with type 1 diabetes mellitus have been reported to have elevated prolactin levels and a possible relationship between prolactin levels and the development of the disease has been proposed. However, some studies show that prolactin mediates beneficial functions in beta cells. Therefore, we review information on the roles of prolactin in type 1 diabetes mellitus.

Content: Here we summarize the functions of prolactin in the immune system and in pancreatic beta cells, in addition, we describe studies related to PRL levels, its regulation and alterations of secretion in patients with type 1 diabetes mellitus.

Summary: Studies in murine models have shown that prolactin protects beta cells from apoptosis, stimulates their proliferation and promotes pancreatic islet revascularization. In addition, some studies in patients with type 1 diabetes mellitus have shown that elevated prolactin levels correlate with better disease control.

Outlook: Prolactin treatment appears to be a promising strategy to improve beta-cell vascularization and proliferation in transplantation and immunotherapies.

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催乳素在1型糖尿病中的调节作用。

目的:已报道1型糖尿病患者催乳素水平升高，并提出催乳素水平与疾病发展之间可能存在的关系。然而，一些研究表明，催乳素介导β细胞的有益功能。因此，我们对催乳素在1型糖尿病中的作用进行综述。内容:本文综述了催乳素在免疫系统和胰腺β细胞中的功能，并对1型糖尿病患者催乳素水平、调节及分泌改变的相关研究进行了综述。摘要:小鼠模型研究表明，催乳素可保护β细胞免于凋亡，刺激其增殖并促进胰岛血运重建。此外，一些对1型糖尿病患者的研究表明，催乳素水平升高与更好的疾病控制有关。展望:在移植和免疫治疗中，催乳素治疗似乎是一种有希望改善β细胞血管化和增殖的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

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0.00%

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期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.