Bergamotane-type sesquiterpenes from the leaves and twigs of Illicium oligandrum and their anti-inflammatory activities

IF 3.2 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Phytochemistry Pub Date : 2023-05-01 DOI:10.1016/j.phytochem.2023.113617
Wen-Rui Li , Jia-Ying Zhao , Mi Li , Xiao-Jing Wang , Guo-Zhu Su , Hai-Qiang Wang , Li Li , Guan-Hua Du , Ru-Bing Wang , Shuang-Gang Ma
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引用次数: 3

Abstract

Eight undescribed β-bergamotene-type sesquiterpene oliganins A-H (1–8) and one known α-bergamotene-type sesquiterpene (9) were isolated from the leaves and twigs of Illicium oligandrum Merr. & Chun. The structures of compounds 18 were elucidated by extensive spectroscopic data, and the absolute configurations were determined by using a modified Mosher's method and electronic circular dichroism calculations. The isolates were further evaluated in terms of their anti-inflammatory potential on nitric oxide (NO) generation in lipopolysaccharide-stimulated RAW264.7 and BV2 cells. Compounds 2 and 8 exhibited potent inhibitory effects on the production of NO with IC50 values ranging from 21.65 to 49.28 μM, which were greater than or comparable to those of dexamethasone (positive control).

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山菖蒲叶、枝中佛手柑烷型倍半萜及其抗炎活性
从八角的叶片和枝条中分离出8种未描述的β-佛手柑烯型倍半萜oliganins A-H(1-8)和1种已知的α-佛手蒿烯型倍全萜(9)&;春。通过大量的光谱数据阐明了化合物1-8的结构,并使用改进的Mosher方法和电子圆二色性计算确定了其绝对构型。进一步评估了分离物在脂多糖刺激的RAW264.7和BV2细胞中产生一氧化氮(NO)的抗炎潜力。化合物2和8对NO的产生表现出强大的抑制作用,IC50值范围为21.65至49.28μM,大于或相当于地塞米松(阳性对照)。
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来源期刊
Phytochemistry
Phytochemistry 生物-植物科学
CiteScore
6.40
自引率
7.90%
发文量
443
审稿时长
39 days
期刊介绍: Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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