Efficacy and safety of stromal vascular fraction on scar revision surgery: a prospective study.

IF 2.9 4区医学 Q2 DERMATOLOGY Journal of Dermatological Treatment Pub Date : 2023-01-19 DOI:10.1080/09546634.2023.2171260

Hyeokjae Kwon, Seokui Lee, Jiyoung Kim, Seung Han Song

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Abstract

Background: Cell-based therapies are popular in the field of reconstructive surgery. The stromal vascular fraction (SVF), comprised of mature adipocytes or blood, reportedly has a regenerative effect; however the mechanism remains unclear. This study aimed to prove the viability and effectiveness of using SVF in scar treatment.

Methods: This prospective double-blind study involved 20 patients who visited an outpatient clinic for 2 years, from July 2016 to July 2018, and underwent scar revision for traumatic or surgical scars. After scar revision surgery performed by a single surgeon, patient scars were divided into experimental and control sides. The subcutaneous layer of the experimental and control sides were injected with 0.1 mL/cm of SVF and normal saline, respectively. Each side was evaluated using the Patient and Observer Scar Assessment Scale (POSAS) before and six months after the surgery.

Results: Of the 20 patients who underwent scar revision surgery and SVF treatment, 4 dropped out for personal reasons. In 11 of 12 POSAS items, the experimental side showed significant improvements compared to the control side.

Conclusions: Although more research is needed, autologous SVF is a valuable source of regenerative medicine that can be swiftly and inexpensively prepared from human fat tissue.

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基质血管分数在瘢痕修复手术中的有效性和安全性:一项前瞻性研究。

背景:细胞疗法在重建外科领域很受欢迎。据报道，由成熟脂肪细胞或血液组成的基质血管部分(SVF)具有再生作用;然而，其机制尚不清楚。本研究旨在证明SVF在疤痕治疗中的可行性和有效性。方法:这项前瞻性双盲研究纳入了20名患者，他们于2016年7月至2018年7月期间在门诊就诊2年，并因创伤或手术疤痕进行了疤痕修复。单个外科医生进行疤痕修复手术后，将患者疤痕分为实验侧和对照侧。实验侧皮下注射0.1 mL/cm SVF，对照组皮下注射生理盐水。术前和术后6个月采用患者和观察者疤痕评估量表(POSAS)对每侧进行评估。结果:20例接受瘢痕修复手术和SVF治疗的患者中，4例因个人原因退出。在12个POSAS项目中的11个，实验方与控制方相比有显著改善。结论:虽然需要更多的研究，但自体SVF是一种有价值的再生医学来源，可以快速和廉价地从人体脂肪组织中制备。

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来源期刊

Journal of Dermatological Treatment 医学-皮肤病学

CiteScore

6.50

自引率

0.00%

发文量

145

审稿时长

6-12 weeks

期刊介绍： The Journal of Dermatological Treatment covers all aspects of the treatment of skin disease, including the use of topical and systematically administered drugs and other forms of therapy. The Journal of Dermatological Treatment is positioned to give dermatologists cutting edge information on new treatments in all areas of dermatology. It also publishes valuable clinical reviews and theoretical papers on dermatological treatments.