{"title":"Synthesis and biological evaluation of tetrazole fused imidazopyridine derivatives as anticancer agents","authors":"Narendhar Reddy Vanam, Jaya Shree Anireddy","doi":"10.1016/j.cdc.2023.101092","DOIUrl":null,"url":null,"abstract":"<div><p>A new series of tetrazole fused imidazopyridine derivatives (<strong>12a-j</strong>) were synthesized and evaluated for their cytotoxic activity against three human cancer cell lines (MCF7, A549, MDA MB-231). All these synthesized compounds were confirmed by <sup>1</sup>H NMR, <sup>13</sup>CNMR and mass spectral analysis. Among them, compounds <strong>12b, 12c, 12d, 12h, 12i</strong> and <strong>12j</strong> showed more potent activity than the positive control doxorubicin.</p></div>","PeriodicalId":269,"journal":{"name":"Chemical Data Collections","volume":null,"pages":null},"PeriodicalIF":2.2180,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Data Collections","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405830023001039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 0
Abstract
A new series of tetrazole fused imidazopyridine derivatives (12a-j) were synthesized and evaluated for their cytotoxic activity against three human cancer cell lines (MCF7, A549, MDA MB-231). All these synthesized compounds were confirmed by 1H NMR, 13CNMR and mass spectral analysis. Among them, compounds 12b, 12c, 12d, 12h, 12i and 12j showed more potent activity than the positive control doxorubicin.
期刊介绍：
Chemical Data Collections (CDC) provides a publication outlet for the increasing need to make research material and data easy to share and re-use. Publication of research data with CDC will allow scientists to: -Make their data easy to find and access -Benefit from the fast publication process -Contribute to proper data citation and attribution -Publish their intermediate and null/negative results -Receive recognition for the work that does not fit traditional article format. The research data will be published as ''data articles'' that support fast and easy submission and quick peer-review processes. Data articles introduced by CDC are short self-contained publications about research materials and data. They must provide the scientific context of the described work and contain the following elements: a title, list of authors (plus affiliations), abstract, keywords, graphical abstract, metadata table, main text and at least three references. The journal welcomes submissions focusing on (but not limited to) the following categories of research output: spectral data, syntheses, crystallographic data, computational simulations, molecular dynamics and models, physicochemical data, etc.
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