Iron-loaded extracellular vesicles: angel or demon?

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Free Radical Research Pub Date : 2023-01-01 DOI:10.1080/10715762.2023.2191813
Huimin Chen, Yuhan Tang
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引用次数: 1

Abstract

Extracellular vesicles (EVs) are identified as a non-classical way to mediate iron efflux except ferroportin. Interestingly, recent studies indicated that EVs pathway is a novel way involved in iron efflux. Mitochondria-derived vesicles (MDVs) are the potential mediator to load mitochondrial iron into EVs. Additionally, iron-replete cells resist excess iron-induced damage by secreting iron-loaded EVs, and the uptake of these EVs induces oxidative damage in the recipient cell. Importantly, iron-loaded EVs play a key role in aberrant iron distribution, which drives the progress of diseases like nonalcoholic fatty liver disease (NAFLD) and neurodegenerative diseases. Herein, we summarize extant research on intracellular iron export with an emphasis on EVs and put our eyes on the relationship between iron-loaded EVs with both parent and target cells. Iron-loaded EVs will be an important avenue for later research on their vital role in iron redistribution.

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含铁细胞外囊泡:天使还是恶魔?
细胞外囊泡(EVs)是除运铁蛋白外介导铁外排的一种非经典途径。有趣的是,最近的研究表明,ev途径是参与铁外排的新途径。线粒体源性囊泡(mdv)是将线粒体铁装载到ev中的潜在介质。此外,富含铁的细胞通过分泌装载铁的ev来抵抗过量铁诱导的损伤,这些ev的摄取在受体细胞中诱导氧化损伤。重要的是,铁负载ev在铁的异常分布中发挥关键作用,从而推动非酒精性脂肪性肝病(NAFLD)和神经退行性疾病等疾病的进展。在此,我们总结了细胞内铁输出的现有研究,重点是ev,并把我们的目光放在了铁负载ev与亲本和靶细胞之间的关系。载铁电动汽车将成为今后研究其在铁再分配中的重要作用的重要途径。
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来源期刊
Free Radical Research
Free Radical Research 生物-生化与分子生物学
CiteScore
6.70
自引率
0.00%
发文量
47
审稿时长
3 months
期刊介绍: Free Radical Research publishes high-quality research papers, hypotheses and reviews in free radicals and other reactive species in biological, clinical, environmental and other systems; redox signalling; antioxidants, including diet-derived antioxidants and other relevant aspects of human nutrition; and oxidative damage, mechanisms and measurement.
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