Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI:10.1016/j.semcdb.2022.03.023
Anna Picca , Flora Guerra , Riccardo Calvani , Roberta Romano , Hélio José Coelho-Junior , Cecilia Bucci , Christiaan Leeuwenburgh , Emanuele Marzetti
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引用次数: 10

Abstract

Mitochondrial remodeling is crucial to meet the bioenergetic demand to support muscle contractile activity during daily tasks and muscle regeneration following injury. A set of mitochondrial quality control (MQC) processes, including mitochondrial biogenesis, dynamics, and mitophagy, are in place to maintain a well-functioning mitochondrial network and support muscle regeneration. Alterations in any of these pathways compromises mitochondrial quality and may potentially lead to impaired myogenesis, defective muscle regeneration, and ultimately loss of muscle function.

Among MQC processes, mitophagy has gained special attention for its implication in the clearance of dysfunctional mitochondria via crosstalk with the endo-lysosomal system, a major cell degradative route. Along this pathway, additional opportunities for mitochondrial disposal have been identified that may also signal at the systemic level. This communication occurs via inclusion of mitochondrial components within membranous shuttles named mitochondrial-derived vesicles (MDVs).

Here, we discuss MDV generation and release as a mitophagy-complementing route for the maintenance of mitochondrial homeostasis in skeletal myocytes. We also illustrate the possible role of muscle-derived MDVs in immune signaling during muscle remodeling and adaptation.

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骨骼肌重构和适应中的线粒体源性囊泡
线粒体重塑对于满足生物能量需求至关重要,以支持日常任务中的肌肉收缩活动和损伤后的肌肉再生。一套线粒体质量控制(MQC)过程,包括线粒体生物发生、动力学和线粒体自噬,已到位,以维持功能良好的线粒体网络并支持肌肉再生。这些途径中的任何一种的改变都会损害线粒体的质量,并可能导致肌肉生成受损、肌肉再生缺陷,最终导致肌肉功能丧失。在MQC过程中,线粒体自噬因其通过与内溶酶体系统(一种主要的细胞降解途径)的相互作用清除功能失调的线粒体而受到特别关注。沿着这一途径,已经确定了线粒体处置的额外机会,这也可能是系统水平的信号。这种通讯是通过将线粒体成分包含在称为线粒体衍生囊泡(MDV)的膜梭中而发生的。在这里,我们讨论了MDV的产生和释放,作为线粒体自噬的补充途径,以维持骨骼肌细胞的线粒体稳态。我们还阐明了肌肉来源的MDV在肌肉重塑和适应过程中的免疫信号传导中的可能作用。
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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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