{"title":"Compact laser spectroscopic sensor head prototype for time-resolved breath oxygen monitoring.","authors":"Link Patrick, Gerard Wysocki","doi":"10.1088/1752-7163/acb07a","DOIUrl":null,"url":null,"abstract":"<p><p>A small and lightweight optical sensor head prototype with a disposable airway adapter for continuous mainstream monitoring of oxygen at high sampling rate is designed and tested on an optical benchtop. In terms of its size and functionality, the sensor head design is similar to current capnography systems from leading medical equipment manufacturers, and it has been designed within constraints of potential applications in direct breath oxygen monitoring that require direct interaction with the gas inside a breathing tube. The measurement precision of 0.1% O<sub>2</sub>with a 10 ms integration time are well within the performance required for breath O<sub>2</sub>monitoring applications.</p>","PeriodicalId":15306,"journal":{"name":"Journal of breath research","volume":"17 2","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of breath research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1088/1752-7163/acb07a","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
A small and lightweight optical sensor head prototype with a disposable airway adapter for continuous mainstream monitoring of oxygen at high sampling rate is designed and tested on an optical benchtop. In terms of its size and functionality, the sensor head design is similar to current capnography systems from leading medical equipment manufacturers, and it has been designed within constraints of potential applications in direct breath oxygen monitoring that require direct interaction with the gas inside a breathing tube. The measurement precision of 0.1% O2with a 10 ms integration time are well within the performance required for breath O2monitoring applications.
期刊介绍：
Journal of Breath Research is dedicated to all aspects of scientific breath research. The traditional focus is on analysis of volatile compounds and aerosols in exhaled breath for the investigation of exogenous exposures, metabolism, toxicology, health status and the diagnosis of disease and breath odours. The journal also welcomes other breath-related topics.
Typical areas of interest include:
Big laboratory instrumentation: describing new state-of-the-art analytical instrumentation capable of performing high-resolution discovery and targeted breath research; exploiting complex technologies drawn from other areas of biochemistry and genetics for breath research.
Engineering solutions: developing new breath sampling technologies for condensate and aerosols, for chemical and optical sensors, for extraction and sample preparation methods, for automation and standardization, and for multiplex analyses to preserve the breath matrix and facilitating analytical throughput. Measure exhaled constituents (e.g. CO2, acetone, isoprene) as markers of human presence or mitigate such contaminants in enclosed environments.
Human and animal in vivo studies: decoding the ''breath exposome'', implementing exposure and intervention studies, performing cross-sectional and case-control research, assaying immune and inflammatory response, and testing mammalian host response to infections and exogenous exposures to develop information directly applicable to systems biology. Studying inhalation toxicology; inhaled breath as a source of internal dose; resultant blood, breath and urinary biomarkers linked to inhalation pathway.
Cellular and molecular level in vitro studies.
Clinical, pharmacological and forensic applications.
Mathematical, statistical and graphical data interpretation.
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