Development of Diagnostic Recommendations for Vitreoretinal Lymphoma.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY Ocular Immunology and Inflammation Pub Date : 2024-09-01 Epub Date: 2023-02-09 DOI:10.1080/09273948.2023.2173242

Xiao Zhang, Yan Zhang, Wenxue Guan, Dongmei Zou, Chan Zhao, Fei Gao, Rong-Ping Dai, Wei-Hong Yu, You-Xin Chen, Han-Yi Min, Meifen Zhang, Wei Zhang, Xiaoyan Peng

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Abstract

Purpose: To develop diagnostic recommendations for diffuse large B-cell vitreoretinal lymphoma (VRL) in Chinese patients.

Methods: Retrospective observational case series. Seventy-three eyes of 40 VRL patients and 8 control patients were analyzed. Eighteen patients from Beijing Tongren Hospital and 46 patients from literature were involved as validations.

Results: Diagnostic methods included (1) typical clinical manifestations; (2) vitreous cytology; (3) immunohistochemical examination of vitreous or choroid/retina; (4) aqueous humor or vitreous cytokine; (5) vitreous cell gene rearrangement; (6) vitreous flow cytometry. If patients meet (1)+(2)+(3), or if they meet (1), and two of (4), (5), (6) are positive, they can be diagnosed as VRL. The sensitivity and specificity values for accurate diagnosis were 0.975 and 1.00. One hundred percent eyes from Beijing Tongren Hospital and 92.7% eyes from literature can be diagnosed.

Conclusion: We developed diagnostic recommendations for diffuse large B-cell VRL through vitreous cytology combined with multiple auxiliary examinations.

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制定玻璃体视网膜淋巴瘤诊断建议。

目的：制定中国患者弥漫大 B 细胞玻璃体视网膜淋巴瘤（VRL）的诊断建议：方法：回顾性观察病例系列。分析了 40 名 VRL 患者和 8 名对照组患者的 73 只眼睛。18例来自北京同仁医院的患者和46例来自文献的患者作为验证：诊断方法包括：（1）典型临床表现；（2）玻璃体细胞学检查；（3）玻璃体或脉络膜/视网膜免疫组化检查；（4）房水或玻璃体细胞因子；（5）玻璃体细胞基因重排；（6）玻璃体流式细胞术。如果患者符合(1)+(2)+(3)，或符合(1)，且(4)、(5)、(6)中的两项呈阳性，则可诊断为 VRL。准确诊断的灵敏度和特异度分别为 0.975 和 1.00。北京同仁医院100%的眼和文献中92.7%的眼可以确诊：通过玻璃体细胞学结合多种辅助检查，我们提出了弥漫大 B 细胞 VRL 的诊断建议。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.

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