A comprehensive overview on Micro RNA signature in type 2 diabetes Mellitus and its complications.

IF 1.5 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Indian Journal of Clinical Biochemistry Pub Date : 2023-04-01 DOI:10.1007/s12291-022-01069-1

Sanjukta Mishra, Jyotirmayee Bahinipati, RajLaxmi Sarangi, Soumya Ranjan Mohapatra, Swarnalata Das, Amaresh Mishra

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Abstract

MicroRNAs (miRNAs) are small endogenous, non-coding RNA molecules that can modulate the expression of their target genes. Since its discovery, an enormous breakthrough has been established regarding its biogenesis and pathophysiological action, which has revolutionized the field of molecular biology. In addition, recent studies have identified the existence of stable extracellular/circulating miRNAs tissues and in biological fluids like blood where they are safeguarded from endogenous ribonuclease activity. Type 2 diabetes mellitus (T2DM) has emerged as a prime health issue worldwide. Incidence has increased considerably over the past decade. There are various tests that have been employed to diagnose T2DM. But for early detection and development, the establishment of biomarkers are of paramount importance. Contemporary evidence also validates the signature of a set of this epigenetic factor miRNA in the development of various diseases, including T2DM. This article reviews the contemporary corroboration associating miRNAs and T2DM and emphasizes the potential role of miRNA as a circulatory biomarker that could alert the growing prevalence of T2DM. Also, it acknowledges the valuable compendium of information regarding biogenesis and functional role of circulating miRNA in insulin resistance which is intimately linked to T2DM.

Supplementary information: The online version contains supplementary material available at 10.1007/s12291-022-01069-1.

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2型糖尿病及其并发症的微RNA信号研究综述

MicroRNAs (miRNAs)是内源性的非编码小RNA分子，可以调节其靶基因的表达。自发现以来，对其生物发生和病理生理作用的研究取得了巨大的突破，使分子生物学领域发生了革命性的变化。此外，最近的研究已经确定了稳定的细胞外/循环miRNAs存在于组织和血液等生物液体中，在那里它们受到内源性核糖核酸酶活性的保护。2型糖尿病(T2DM)已成为世界范围内的主要健康问题。发病率在过去十年中显著增加。有各种各样的测试被用来诊断T2DM。但对于早期发现和发展，生物标志物的建立是至关重要的。当代证据也证实了一组这种表观遗传因子miRNA在包括T2DM在内的各种疾病的发展中所起的作用。本文回顾了miRNA与T2DM相关的当代证据，并强调了miRNA作为一种循环生物标志物的潜在作用，可以提醒日益增长的T2DM患病率。此外，它承认循环miRNA在与T2DM密切相关的胰岛素抵抗中的生物发生和功能作用的有价值的信息摘要。补充信息:在线版本包含补充资料，提供地址为10.1007/s12291-022-01069-1。

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来源期刊

Indian Journal of Clinical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

4.50

自引率

4.80%

发文量

期刊介绍： The primary mission of the journal is to promote improvement in the health and well-being of community through the development and practice of clinical biochemistry and dissemination of knowledge and recent advances in this discipline among professionals, diagnostics industry, government and non-government organizations. Indian Journal of Clinical Biochemistry (IJCB) publishes peer reviewed articles that contribute to the existing knowledge in all fields of Clinical biochemistry, either experimental or theoretical, particularly deal with the applications of biochemistry, molecular biology, genetics, biotechnology, and immunology to the diagnosis, treatment, monitoring and prevention of human diseases. The articles published also include those covering the analytical and molecular diagnostic techniques, instrumentation, data processing, quality assurance and accreditation aspects of the clinical investigations in which chemistry has played a major role, or laboratory animal studies with biochemical and clinical relevance.