Pub Date : 2024-10-01Epub Date: 2024-09-20DOI: 10.1007/s12291-024-01270-4
Prasenjit Mitra, Shruti Gupta, Praveen Sharma
{"title":"Double Trouble: Unravelling the Health Hazards of Microplastics and Heavy Metals.","authors":"Prasenjit Mitra, Shruti Gupta, Praveen Sharma","doi":"10.1007/s12291-024-01270-4","DOIUrl":"https://doi.org/10.1007/s12291-024-01270-4","url":null,"abstract":"","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"39 4","pages":"447-449"},"PeriodicalIF":1.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01Epub Date: 2024-06-26DOI: 10.1007/s12291-024-01246-4
Rajendra Prasad, Sonia Deswal, Munish Kumar
{"title":"New Perspectives on Selenium and Selenoproteins in Cardiomyopathy.","authors":"Rajendra Prasad, Sonia Deswal, Munish Kumar","doi":"10.1007/s12291-024-01246-4","DOIUrl":"10.1007/s12291-024-01246-4","url":null,"abstract":"","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"39 3","pages":"299-300"},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study investigated the hepatocurative activity of the bulk alkaloids of Zanthoxylum zanthoxyloides in a tetrachloromethane (CCl4)-induced hepatotoxicity model in rats. The hepatocurative activity of the alkaloids at 200, 400 and 600 mg/kg doses was demonstrated by the assay of both enzymic and non-enzymic parameters. Sections of the liver were also subjected to histological examinations. Mapping techniques and data visualization approaches were adopted in finding relationships between the enzymic and non-enzymic parameters and the treatment groups. The bulk alkaloids caused dose-dependent effects on both the enzymic and non-enzymic parameters. The bulk alkaloids elicited a significant reduction (p < 0.05) in all liver and antioxidant enzymes activities compared with the untreated. The 600 mg/kg dose caused the restoration of the ALP, ALT and AST to 76.16, 10.72 and 11.83 iU/L respectively similar to the standard butylated hydroxytoluene. The 600 mg/kg dose also caused a slight increase in the activities of SOD, catalase and GPx to 11.45. 1.37 and 11.66 iU/L respectively when compared with the untreated rats. In the non-enzymic assays, the 600 mg/kg dose elicited a significant (p < 0.05) upregulation in the total bilirubin (1.18 mg/100 mL), total protein (3.75 g/dL), HDL (1.80 mMol/L) and vitamin C (2.41 mg/dL) and decrease in the CHOL (3.35 g/dL), TAG (1.85 mMol/L), LDL (0.67 mMol/L), BUN (39.55 mg/dL) and MDA (1.13 nMol/mL) when compared with the untreated rats. The restoration of the natural histo-architecture of the CCl4-damaged liver by the alkaloids further evidenced the hepatocurative activity of the bulk alkaloids.
本研究调查了在四氯甲烷（CCl4）诱导的大鼠肝毒性模型中 Zanthoxylum zanthoxyloides 大块生物碱的肝细胞活性。生物碱在 200、400 和 600 毫克/千克剂量下的肝毒性活性是通过酶和非酶参数的检测来证明的。肝脏切片也进行了组织学检查。在发现酶和非酶参数与处理组之间的关系时，采用了绘图技术和数据可视化方法。大块生物碱对酶和非酶参数都产生了剂量依赖性影响。大块生物碱能显著减少（p p 4）生物碱对肝脏的损伤，这进一步证明了大块生物碱的肝癌活性。
{"title":"The Hepatocurative Effects of <i>Zanthoxylum zanthoxyloides</i> Alkaloids on Tetrachloromethane-Induced Hepatotoxicity on Albino Rats.","authors":"Thecla Okeahunwa Ayoka, Ngwu Nwachukwu, Aloysius Chinedu Ene, Chidi Uzoma Igwe, Charles Okeke Nnadi","doi":"10.1007/s12291-022-01095-z","DOIUrl":"https://doi.org/10.1007/s12291-022-01095-z","url":null,"abstract":"<p><p>The study investigated the hepatocurative activity of the bulk alkaloids of <i>Zanthoxylum zanthoxyloides</i> in a tetrachloromethane (CCl<sub>4</sub>)-induced hepatotoxicity model in rats. The hepatocurative activity of the alkaloids at 200, 400 and 600 mg/kg doses was demonstrated by the assay of both enzymic and non-enzymic parameters. Sections of the liver were also subjected to histological examinations. Mapping techniques and data visualization approaches were adopted in finding relationships between the enzymic and non-enzymic parameters and the treatment groups. The bulk alkaloids caused dose-dependent effects on both the enzymic and non-enzymic parameters. The bulk alkaloids elicited a significant reduction (<i>p</i> < 0.05) in all liver and antioxidant enzymes activities compared with the untreated. The 600 mg/kg dose caused the restoration of the ALP, ALT and AST to 76.16, 10.72 and 11.83 iU/L respectively similar to the standard butylated hydroxytoluene. The 600 mg/kg dose also caused a slight increase in the activities of SOD, catalase and GPx to 11.45. 1.37 and 11.66 iU/L respectively when compared with the untreated rats. In the non-enzymic assays, the 600 mg/kg dose elicited a significant (<i>p</i> < 0.05) upregulation in the total bilirubin (1.18 mg/100 mL), total protein (3.75 g/dL), HDL (1.80 mMol/L) and vitamin C (2.41 mg/dL) and decrease in the CHOL (3.35 g/dL), TAG (1.85 mMol/L), LDL (0.67 mMol/L), BUN (39.55 mg/dL) and MDA (1.13 nMol/mL) when compared with the untreated rats. The restoration of the natural histo-architecture of the CCl<sub>4</sub>-damaged liver by the alkaloids further evidenced the hepatocurative activity of the bulk alkaloids.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"39 2","pages":"188-196"},"PeriodicalIF":2.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10987411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.1007/s12291-023-01166-9
Abdul Jalil, Hassan Hadi Al-Kazzaz, Firas A. Hassan, Safaa Halool Mohammed, M. Merza, Tahani Aslandook, Ahmed Elewadi, Ali Fadhil, Ali Alsalamy
{"title":"Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy","authors":"Abdul Jalil, Hassan Hadi Al-Kazzaz, Firas A. Hassan, Safaa Halool Mohammed, M. Merza, Tahani Aslandook, Ahmed Elewadi, Ali Fadhil, Ali Alsalamy","doi":"10.1007/s12291-023-01166-9","DOIUrl":"https://doi.org/10.1007/s12291-023-01166-9","url":null,"abstract":"","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"57 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.1007/s12291-023-01167-8
D. Kumari, N. Nair, R. Bedwal
{"title":"Effects of Dietary Zinc Deficiency and Supplementation on Prepubertal Rat Testes: Sulfhydryl and Antioxidant Status","authors":"D. Kumari, N. Nair, R. Bedwal","doi":"10.1007/s12291-023-01167-8","DOIUrl":"https://doi.org/10.1007/s12291-023-01167-8","url":null,"abstract":"","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"2 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.1007/s12291-023-01169-6
Khairatul Nisa, Najeebul Tarfeen, S. Mir, Zulaykha Khurshid, Mir Bilal Ahmad, Saba Wani, Humaira Bhat, B. Ganai
{"title":"Effect of Junk Food on Hormonal and Metabolic Manifestations in Polycystic Ovarian Syndrome Phenotypes: A Case–Control Study of Kashmiri Population","authors":"Khairatul Nisa, Najeebul Tarfeen, S. Mir, Zulaykha Khurshid, Mir Bilal Ahmad, Saba Wani, Humaira Bhat, B. Ganai","doi":"10.1007/s12291-023-01169-6","DOIUrl":"https://doi.org/10.1007/s12291-023-01169-6","url":null,"abstract":"","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"2012 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-18DOI: 10.1007/s12291-023-01173-w
N. Indika, Hemantha Peiris, N. Deutz, Rasika Perera
{"title":"Optimization of Automated Dimethylmethylene Blue Assay for Quantification of Pediatric Urine Samples","authors":"N. Indika, Hemantha Peiris, N. Deutz, Rasika Perera","doi":"10.1007/s12291-023-01173-w","DOIUrl":"https://doi.org/10.1007/s12291-023-01173-w","url":null,"abstract":"","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"221 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139174944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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