History of traumatic brain injury does not alter course of neurocognitive decline in older adults with and without cognitive impairment.

IF 2.6 3区心理学 Q3 NEUROSCIENCES Neuropsychology Pub Date : 2023-11-01 Epub Date: 2023-04-06 DOI:10.1037/neu0000892

Jeff Schaffert, Hsueh-Sheng Chiang, Hudaisa Fatima, Christian LoBue, John Hart, C Munro Cullum

{"title":"History of traumatic brain injury does not alter course of neurocognitive decline in older adults with and without cognitive impairment.","authors":"Jeff Schaffert, Hsueh-Sheng Chiang, Hudaisa Fatima, Christian LoBue, John Hart, C Munro Cullum","doi":"10.1037/neu0000892","DOIUrl":null,"url":null,"abstract":"Objective: Traumatic brain injury (TBI) history is associated with dementia risk, but it is unclear whether TBI history significantly hastens neurocognitive decline in older adults.Method: Data were derived from the National Alzheimer's Coordinating Center (NACC) data set. Participants with a history of TBI (TBI +; n = 1,467) were matched to individuals without a history of TBI (TBI-; n = 1,467) based on age (50-97, M = 71.61, SD = 8.40), sex, education, race, ethnicity, cognitive diagnosis, functional decline, number of Apolipoprotein ε4 (APOE ε4) alleles, and number of annual visits (3-6). Mixed linear models were used to assess longitudinal neuropsychological test composite scores of executive functioning/attention/speed, language, and memory in TBI + and TBI- participants. Interactions between TBI and demographics, APOE ε4 status, and cognitive diagnosis were also examined.Results: Longitudinal neuropsychological functioning did not differ between TBI groups (p's > .001). There was a significant three-way interaction (age, TBI history, time) in language (F[20, 5750.1] = 3.133, p < .001) and memory performance (F[20, 6580.8] = 3.386, p < .001), but post hoc analyses revealed TBI history was not driving this relationship (all p's > .096). No significant interactions were observed between TBI history and sex, education, race/ethnicity, number of APOE ε4 alleles, or cognitive diagnosis (p's > .001).Conclusions: Findings suggest TBI history, regardless of demographic factors, APOE ε4 status, or cognitive diagnosis, does not alter the course of neurocognitive functioning later-in-life in older adults with or without cognitive impairment. Future clinicopathological longitudinal studies that well-characterize head injuries and the associated clinical course are needed to help clarify the mechanism in which TBI may increase dementia risk. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"923-932"},"PeriodicalIF":2.6000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556197/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropsychology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1037/neu0000892","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/4/6 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Traumatic brain injury (TBI) history is associated with dementia risk, but it is unclear whether TBI history significantly hastens neurocognitive decline in older adults.

Method: Data were derived from the National Alzheimer's Coordinating Center (NACC) data set. Participants with a history of TBI (TBI +; n = 1,467) were matched to individuals without a history of TBI (TBI-; n = 1,467) based on age (50-97, M = 71.61, SD = 8.40), sex, education, race, ethnicity, cognitive diagnosis, functional decline, number of Apolipoprotein ε4 (APOE ε4) alleles, and number of annual visits (3-6). Mixed linear models were used to assess longitudinal neuropsychological test composite scores of executive functioning/attention/speed, language, and memory in TBI + and TBI- participants. Interactions between TBI and demographics, APOE ε4 status, and cognitive diagnosis were also examined.

Results: Longitudinal neuropsychological functioning did not differ between TBI groups (p's > .001). There was a significant three-way interaction (age, TBI history, time) in language (F[20, 5750.1] = 3.133, p < .001) and memory performance (F[20, 6580.8] = 3.386, p < .001), but post hoc analyses revealed TBI history was not driving this relationship (all p's > .096). No significant interactions were observed between TBI history and sex, education, race/ethnicity, number of APOE ε4 alleles, or cognitive diagnosis (p's > .001).

Conclusions: Findings suggest TBI history, regardless of demographic factors, APOE ε4 status, or cognitive diagnosis, does not alter the course of neurocognitive functioning later-in-life in older adults with or without cognitive impairment. Future clinicopathological longitudinal studies that well-characterize head injuries and the associated clinical course are needed to help clarify the mechanism in which TBI may increase dementia risk. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

创伤性脑损伤史不会改变有或没有认知障碍的老年人神经认知能力下降的过程。

目的：创伤性脑损伤（TBI）史与痴呆风险相关，但尚不清楚TBI史是否会显著加速老年人神经认知能力的下降。方法：数据来源于国家阿尔茨海默病协调中心（NACC）的数据集。根据年龄（50-97，M=71.61，SD=8.40）、性别、教育程度、种族、民族、认知诊断、功能下降、载脂蛋白ε4（APOEε4）等位基因数量和每年就诊次数（3-6），将有TBI病史（TBI+；n=1467）的参与者与无TBI病史的个体（TBI-；n=1466）进行匹配。混合线性模型用于评估TBI+和TBI-参与者的执行功能/注意力/速度、语言和记忆的纵向神经心理测试综合得分。还检查了TBI与人口统计学、APOEε4状态和认知诊断之间的相互作用。结果：TBI组之间的纵向神经心理功能没有差异（p＞0.001）。在语言（F[20575.01]＝3.133，p＜0.001）和记忆表现（F[20658.8]＝3.386，p＜.001）方面存在显著的三方交互作用（年龄、TBI史、时间），但事后分析显示，TBI病史并不是这种关系的驱动因素（所有p均>.096）。在TBI病史与性别、教育、种族/民族、APOEε4等位基因数量或认知诊断之间没有观察到显著的相互作用（p>.001），不会改变有或没有认知障碍的老年人以后的神经认知功能过程。未来的临床病理纵向研究需要很好地描述头部损伤和相关的临床过程，以帮助阐明TBI可能增加痴呆风险的机制。（PsycInfo数据库记录（c）2023 APA，保留所有权利）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Neuropsychology 医学-神经科学

CiteScore

4.10

自引率

4.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.