The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY Turkish neurosurgery Pub Date : 2023-01-01 DOI:10.5137/1019-5149.JTN.38233-22.3

Gokhan Gurkan, Mumin Alper Erdogan, Gokhan Karahan, Huseyin Kaya, Gurkan Yigitturk, Ceren Kizmazoglu, Oytun Erbas

{"title":"The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10.","authors":"Gokhan Gurkan, Mumin Alper Erdogan, Gokhan Karahan, Huseyin Kaya, Gurkan Yigitturk, Ceren Kizmazoglu, Oytun Erbas","doi":"10.5137/1019-5149.JTN.38233-22.3","DOIUrl":null,"url":null,"abstract":"Aim: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17.Material and methods: The study was conducted with 30 male Sprague Dawley albino mature rats, of which 10 formed the control group, 10 were surgically treated and administered saline (group S), and another 10 were surgically treated and administered digoxin (group D). Motor functions and immunohistochemical and biochemical variables of the rats were assessed after therapy.Results: The amplitude of the inclined plane test scores and the compound muscle action potential levels were greater in group D than in group S. Likewise, there were higher nerve growth factor percentages, higher axon counts, and lower fibrosis score percentages in group D than is group S. Lastly, lower tissue malondialdehyde and plasma IL-17 levels were determined in group D, while the IL-10 level was higher.Conclusion: Digoxin contributes to nerve healing and neuroprotective effect by demonstrating its anti-inflammatory effect on IL-17. It can be considered an adjunctive therapy for peripheral nerve injury.","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":"33 2","pages":"258-264"},"PeriodicalIF":0.9000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5137/1019-5149.JTN.38233-22.3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17.

Material and methods: The study was conducted with 30 male Sprague Dawley albino mature rats, of which 10 formed the control group, 10 were surgically treated and administered saline (group S), and another 10 were surgically treated and administered digoxin (group D). Motor functions and immunohistochemical and biochemical variables of the rats were assessed after therapy.

Results: The amplitude of the inclined plane test scores and the compound muscle action potential levels were greater in group D than in group S. Likewise, there were higher nerve growth factor percentages, higher axon counts, and lower fibrosis score percentages in group D than is group S. Lastly, lower tissue malondialdehyde and plasma IL-17 levels were determined in group D, while the IL-10 level was higher.

Conclusion: Digoxin contributes to nerve healing and neuroprotective effect by demonstrating its anti-inflammatory effect on IL-17. It can be considered an adjunctive therapy for peripheral nerve injury.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

地高辛治疗周围神经损伤的疗效及其与IL-17/IL-10的关系。

目的:探讨地高辛对周围神经损伤的治疗作用及其对白细胞介素-17的抗炎作用。材料与方法:选取30只雄性白化病成年大鼠，其中10只为对照组，10只手术治疗并给予生理盐水(S组)，10只手术治疗并给予地高辛(D组)。观察治疗后大鼠的运动功能及免疫组织化学和生化指标。结果:D组大鼠斜面测试评分幅度和复合肌动作电位水平均高于s组。D组神经生长因子百分比、轴突数量和纤维化评分百分比均高于s组。D组组织丙二醛和血浆IL-17水平均低于s组，IL-10水平高于s组。结论:地高辛对IL-17的抗炎作用有助于神经愈合和神经保护。它可以被认为是周围神经损伤的辅助治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Turkish neurosurgery 医学-临床神经学

CiteScore

1.50

自引率

12.50%

发文量

126

审稿时长

2 months

期刊介绍： Turkish Neurosurgery is a peer-reviewed, multidisciplinary, open access and totally free journal directed at an audience of neurosurgery physicians and scientists. The official language of the journal is English. The journal publishes original articles in the form of clinical and basic research. Turkish Neurosurgery will only publish studies that have institutional review board (IRB) approval and have strictly observed an acceptable follow-up period. With the exception of reference presentation, Turkish Neurosurgery requires that all manuscripts be prepared in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals.