Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY Human Psychopharmacology: Clinical and Experimental Pub Date : 2022-10-17 DOI:10.1002/hup.2856

Faiz M. Kassim

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引用次数: 4

Abstract

Objectives

This research aimed to systematically review the acute effects of amphetamine (AMP), a dopamine-releasing agent, on working memory (WM) and other cognitive performances. The investigation also aimed to review the impact of personality traits on the subjective and objective effects of AMP and possible links between personality traits and effects of AMP.

Methods

Previous double-blind controlled studies assessing the main effects of AMP on WM and other cognitive performances in healthy volunteers were systematically reviewed. An electronic search was performed in the PUBMED and SCOPUS databases. Narrative reviews of the influence of personality traits on the subjective and objective effects of AMP were included.

Results

Nineteen WM studies were included in the current review. Seven studies found effects of AMP on spatial WM, but only one study found the effect of AMP on verbal WM. Thirty-seven independent studies on other aspects of cognitive performance were identified. Twenty-two reported effects of AMP on cognitive functions. Studies also showed that personality traits are associated with the subjective effects of AMP. However, few studies reported the impacts of personality traits on the objective (such as WM) effects of AMP.

Conclusion

Overall, findings indicate that AMP has mixed-effects on spatial WM and other cognitive functions, but it lacks effects on verbal WM. Although there are insufficient studies on objective measures, studies also indicated that the subjective effects of AMP administration are linked to between-person variations in personality traits.

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系统回顾安非他明对健康个体的工作记忆和其他认知表现的急性影响，重点是人格特质的潜在影响

本研究旨在系统回顾多巴胺释放剂安非他明(AMP)对工作记忆(WM)和其他认知能力的急性影响。本研究还旨在探讨人格特质对AMP主客观效应的影响，以及人格特质与AMP效应之间可能存在的联系。方法系统回顾以往评估AMP对健康志愿者WM和其他认知表现主要影响的双盲对照研究。在PUBMED和SCOPUS数据库中进行电子检索。对人格特质对AMP主客观效应的影响进行了叙述综述。结果本综述纳入了19项WM研究。七项研究发现了AMP对空间记忆的影响，但只有一项研究发现了AMP对言语记忆的影响。对认知表现的其他方面进行了37项独立研究。22例报告了AMP对认知功能的影响。研究还表明，人格特质与AMP的主观效应有关，但人格特质对AMP的客观(如WM)效应的影响研究较少。结论总体而言，AMP对空间WM和其他认知功能具有混合效应，但对言语WM的影响较少。虽然对客观测量的研究不足，但研究也表明，AMP的主观影响与人格特质的人与人之间的差异有关。

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来源期刊

Human Psychopharmacology: Clinical and Experimental 医学-精神病学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Human Psychopharmacology: Clinical and Experimental provides a forum for the evaluation of clinical and experimental research on both new and established psychotropic medicines. Experimental studies of other centrally active drugs, including herbal products, in clinical, social and psychological contexts, as well as clinical/scientific papers on drugs of abuse and drug dependency will also be considered. While the primary purpose of the Journal is to publish the results of clinical research, the results of animal studies relevant to human psychopharmacology are welcome. The following topics are of special interest to the editors and readers of the Journal: -All aspects of clinical psychopharmacology- Efficacy and safety studies of novel and standard psychotropic drugs- Studies of the adverse effects of psychotropic drugs- Effects of psychotropic drugs on normal physiological processes- Geriatric and paediatric psychopharmacology- Ethical and psychosocial aspects of drug use and misuse- Psychopharmacological aspects of sleep and chronobiology- Neuroimaging and psychoactive drugs- Phytopharmacology and psychoactive substances- Drug treatment of neurological disorders- Mechanisms of action of psychotropic drugs- Ethnopsychopharmacology- Pharmacogenetic aspects of mental illness and drug response- Psychometrics: psychopharmacological methods and experimental design