Regeneration of articular cartilage defects: Therapeutic strategies and perspectives.

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING Journal of Tissue Engineering Pub Date : 2023-01-01 DOI:10.1177/20417314231164765
Xueqiang Guo, Lingling Xi, Mengyuan Yu, Zhenlin Fan, Weiyun Wang, Andong Ju, Zhuo Liang, Guangdong Zhou, Wenjie Ren
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引用次数: 4

Abstract

Articular cartilage (AC), a bone-to-bone protective device made of up to 80% water and populated by only one cell type (i.e. chondrocyte), has limited capacity for regeneration and self-repair after being damaged because of its low cell density, alymphatic and avascular nature. Resulting repair of cartilage defects, such as osteoarthritis (OA), is highly challenging in clinical treatment. Fortunately, the development of tissue engineering provides a promising method for growing cells in cartilage regeneration and repair by using hydrogels or the porous scaffolds. In this paper, we review the therapeutic strategies for AC defects, including current treatment methods, engineering/regenerative strategies, recent advances in biomaterials, and present emphasize on the perspectives of gene regulation and therapy of noncoding RNAs (ncRNAs), such as circular RNA (circRNA) and microRNA (miRNA).

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关节软骨缺损的再生:治疗策略与展望。
关节软骨(AC)是一种骨对骨的保护装置,由高达80%的水组成,仅由一种细胞(即软骨细胞)组成,由于其细胞密度低、淋巴细胞和无血管的性质,在受损后再生和自我修复的能力有限。骨关节炎(OA)等软骨缺损的修复在临床治疗中极具挑战性。幸运的是,组织工程的发展为利用水凝胶或多孔支架培养软骨再生和修复细胞提供了一种很有前途的方法。本文综述了AC缺陷的治疗策略,包括目前的治疗方法,工程/再生策略,生物材料的最新进展,并重点介绍了非编码RNA (ncrna)的基因调控和治疗,如环状RNA (circRNA)和微RNA (miRNA)。
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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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