In vitro genotoxicity assessment of French fries from mass catering companies: a preliminary study.

IF 2.5 4区 医学 Q3 GENETICS & HEREDITY Mutagenesis Pub Date : 2023-02-03 DOI:10.1093/mutage/geac021
Julen Sanz-Serrano, Roncesvalles Garayoa, Ana Isabel Vitas, Adela López de Cerain, Amaya Azqueta
{"title":"In vitro genotoxicity assessment of French fries from mass catering companies: a preliminary study.","authors":"Julen Sanz-Serrano,&nbsp;Roncesvalles Garayoa,&nbsp;Ana Isabel Vitas,&nbsp;Adela López de Cerain,&nbsp;Amaya Azqueta","doi":"10.1093/mutage/geac021","DOIUrl":null,"url":null,"abstract":"<p><p>It is generally assumed that French fries are likely to have weak in vitro mutagenic activity, but most studies thereof have only assessed gene mutations. In this article, the genotoxicity of 10 extracts of French fries was assessed using the in vitro micronucleus test (following the principles of the OECD 487 guidelines). Each sample was obtained from a different mass catering company in Navarra (Spain). This assay, together with the Ames test, is recommended in the basic in vitro phase included in the European Food Safety Authority Opinion on Genotoxicity Testing Strategies Applicable to Food and Feed Safety Assessment. Eight of 10 samples from mass catering companies induced chromosomal aberrations in the in vitro micronucleus test. Moreover, French fries deep-fried in the laboratory for different periods of time (0, 3, 5, 10, 20, 30 min) were assessed using the in vitro micronucleus test. Genotoxicity was observed in all time periods from 3 min on. The biological relevance of these results must be further explored.</p>","PeriodicalId":18889,"journal":{"name":"Mutagenesis","volume":"38 1","pages":"51-57"},"PeriodicalIF":2.5000,"publicationDate":"2023-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897018/pdf/","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutagenesis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/mutage/geac021","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 2

Abstract

It is generally assumed that French fries are likely to have weak in vitro mutagenic activity, but most studies thereof have only assessed gene mutations. In this article, the genotoxicity of 10 extracts of French fries was assessed using the in vitro micronucleus test (following the principles of the OECD 487 guidelines). Each sample was obtained from a different mass catering company in Navarra (Spain). This assay, together with the Ames test, is recommended in the basic in vitro phase included in the European Food Safety Authority Opinion on Genotoxicity Testing Strategies Applicable to Food and Feed Safety Assessment. Eight of 10 samples from mass catering companies induced chromosomal aberrations in the in vitro micronucleus test. Moreover, French fries deep-fried in the laboratory for different periods of time (0, 3, 5, 10, 20, 30 min) were assessed using the in vitro micronucleus test. Genotoxicity was observed in all time periods from 3 min on. The biological relevance of these results must be further explored.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
大众餐饮公司炸薯条的体外遗传毒性评价:初步研究。
人们普遍认为炸薯条可能具有较弱的体外诱变活性,但大多数研究仅评估了基因突变。在这篇文章中,使用体外微核试验评估了10种炸薯条提取物的遗传毒性(遵循OECD 487指南的原则)。每个样本都来自西班牙纳瓦拉的一家不同的大众餐饮公司。该试验与Ames试验一起被推荐用于基本体外阶段,包括在欧洲食品安全局关于适用于食品和饲料安全评估的遗传毒性测试策略的意见中。来自大众餐饮公司的10份样品中有8份在体外微核试验中诱发了染色体畸变。此外,采用体外微核试验对实验室中油炸不同时间(0、3、5、10、20、30 min)的炸薯条进行了评估。在3 min后的所有时间内观察遗传毒性。这些结果的生物学相关性必须进一步探索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Mutagenesis
Mutagenesis 生物-毒理学
CiteScore
5.90
自引率
3.70%
发文量
22
审稿时长
6-12 weeks
期刊介绍: Mutagenesis is an international multi-disciplinary journal designed to bring together research aimed at the identification, characterization and elucidation of the mechanisms of action of physical, chemical and biological agents capable of producing genetic change in living organisms and the study of the consequences of such changes.
期刊最新文献
A pooled analysis of host factors that affect nucleotide excision repair in humans. Piper auritum ethanol extract is a potent antimutagen against food-borne aromatic amines: mechanisms of action and chemical composition. Impact of DNA ligase inhibition on the nick sealing of polβ nucleotide insertion products at the downstream steps of base excision repair pathway. Expression of Concern: Divergent molecular profile of PIK3CA gene in arsenic-associated bladder carcinoma. Dihydroquercetin and biochaga reduce H2O2-induced DNA damage in peripheral blood mononuclear cells of obese women in vitro-a pilot study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1