Prognostic value of KI-67 proliferation index in luminal breast cancers.

IF 0.5 4区医学 Q4 SURGERY Cirugia Y Cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.22000043

Şeref Dokcu, Mehmet Ali-Çaparlar, Özhan Çetindağ, Musluh Hakseven, Aydan Eroğlu

{"title":"Prognostic value of KI-67 proliferation index in luminal breast cancers.","authors":"Şeref Dokcu, Mehmet Ali-Çaparlar, Özhan Çetindağ, Musluh Hakseven, Aydan Eroğlu","doi":"10.24875/CIRU.22000043","DOIUrl":null,"url":null,"abstract":"Aim: This study aimed to examine the prognostic significance of the KI-67 proliferation index, especially in breast cancer (BC) patients without HER-2 expression and no nodal involvement.Material and methods: The database of hormone-receptor-positive patients who underwent surgery for BC in our Surgical Oncology Clinic between 2008 and 2020 was retrospectively reviewed and recorded. Patients were categorized based on their KI-67 level, considering the cutoff value of 20%.Results: Our study revealed that tumors with high KI-67 levels were more likely to have a more advanced histological grade (p = 0.00) and size (p = 0.038). In the univariant analysis, KI-67 level was effective on overall survival (p = 0.044) and disease-free survival (p = 0.048). However, we found that there was no independent prognostic factor in the multivariant analysis.Conclusion: Although the Ki-67 proliferation index does not yet have an agreed threshold value and scoring methodology, it can also be used to determine prognosis and evaluate treatment response in some patients.","PeriodicalId":50990,"journal":{"name":"Cirugia Y Cirujanos","volume":"91 1","pages":"1-8"},"PeriodicalIF":0.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cirugia Y Cirujanos","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.24875/CIRU.22000043","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: This study aimed to examine the prognostic significance of the KI-67 proliferation index, especially in breast cancer (BC) patients without HER-2 expression and no nodal involvement.

Material and methods: The database of hormone-receptor-positive patients who underwent surgery for BC in our Surgical Oncology Clinic between 2008 and 2020 was retrospectively reviewed and recorded. Patients were categorized based on their KI-67 level, considering the cutoff value of 20%.

Results: Our study revealed that tumors with high KI-67 levels were more likely to have a more advanced histological grade (p = 0.00) and size (p = 0.038). In the univariant analysis, KI-67 level was effective on overall survival (p = 0.044) and disease-free survival (p = 0.048). However, we found that there was no independent prognostic factor in the multivariant analysis.

Conclusion: Although the Ki-67 proliferation index does not yet have an agreed threshold value and scoring methodology, it can also be used to determine prognosis and evaluate treatment response in some patients.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

KI-67增殖指数在腔内乳腺癌中的预后价值。

目的:本研究旨在探讨KI-67增殖指数在无HER-2表达和无淋巴结累及的乳腺癌(BC)患者中的预后意义。材料和方法:回顾性回顾和记录2008年至2020年在我院外科肿瘤诊所接受BC手术的激素受体阳性患者数据库。根据KI-67水平，考虑20%的临界值对患者进行分类。结果:我们的研究显示，KI-67水平高的肿瘤更有可能具有更高的组织学分级(p = 0.00)和更大的肿瘤(p = 0.038)。在单变量分析中，KI-67水平对总生存期(p = 0.044)和无病生存期(p = 0.048)有效。然而，我们发现在多变量分析中没有独立的预后因素。结论:虽然Ki-67增殖指数尚未有统一的阈值和评分方法，但在部分患者中，Ki-67增殖指数也可用于判断预后和评价治疗反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Cirugia Y Cirujanos 医学-外科

CiteScore

0.90

自引率

20.00%

发文量

207

审稿时长

6-12 weeks

期刊介绍： Cirugía y Cirujanoses exponente del desarrollo académico, científico, médico, quirúrgico y tecnológico en materia de salud en México y en el ámbito internacional. Es una revista bimestral, open access, revisada por pares, que publica en español y en inglés (traducido sin coste para los autores) artículos científicos originales, casos clínicos, artículos de revisión de interés general y cartas al editor. Los artículos se seleccionan y publican siguiendo un riguroso análisis, de acuerdo con los estándares internacionalmente aceptados. Sus espacios están abiertos a los académicos, así como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos.