The Naked Mole-Rat as a Model for Healthy Aging.

IF 8.7 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Annual Review of Animal Biosciences Pub Date : 2023-02-15 DOI:10.1146/annurev-animal-050322-074744

Kaori Oka, Masanori Yamakawa, Yoshimi Kawamura, Nobuyuki Kutsukake, Kyoko Miura

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引用次数: 6

Abstract

Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and resistance to age-related functional decline/diseases. Specifically, they do not display increased mortality with age, maintain several physiological functions until nearly the end of their lifetime, and rarely develop cancer and Alzheimer's disease. NMRs live in a hypoxic environment in underground colonies in East Africa and are highly tolerant of hypoxia. These unique characteristics of NMRs have attracted considerable interest from zoological and biomedical researchers. This review summarizes previous studies of the ecology, hypoxia tolerance, longevity/delayed aging, and cancer resistance of NMRs and discusses possible mechanisms contributing to their healthy aging. In addition, we discuss current issues and future perspectives to fully elucidate the mechanisms underlying delayed aging and resistance to age-related diseases in NMRs.

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裸鼹鼠作为健康衰老的模型。

裸鼹鼠(Heterocephalus glaber, NMRs)是世界上最长寿的啮齿动物，最长寿命可达37岁。它们表现出延迟衰老表型和对年龄相关功能衰退/疾病的抵抗力。具体来说，他们的死亡率不会随着年龄的增长而增加，直到接近生命的尽头，他们还能保持一些生理功能，很少患癌症和阿尔茨海默病。NMRs生活在东非地下的低氧环境中，对缺氧具有高度的耐受性。核磁共振的这些独特特征引起了动物学和生物医学研究人员的极大兴趣。本文综述了nmr的生态学、耐缺氧性、长寿/延缓衰老和抗肿瘤等方面的研究，并讨论了nmr健康衰老的可能机制。此外，我们讨论了当前的问题和未来的观点，以充分阐明nmr中延迟衰老和抵抗年龄相关疾病的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY

CiteScore

21.30

自引率

0.80%

发文量

期刊介绍： The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.