Implications of mitochondrial fusion and fission in skeletal muscle mass and health

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI:10.1016/j.semcdb.2022.02.011
Vanina Romanello , Marco Sandri
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引用次数: 10

Abstract

The continuous dynamic reshaping of mitochondria by fusion and fission events is critical to keep mitochondrial quality and function under control in response to changes in energy and stress. Maintaining a functional, highly interconnected mitochondrial reticulum ensures rapid energy production and distribution. Moreover, mitochondrial networks act as dynamic signaling hub to adapt to the metabolic demands imposed by contraction, energy expenditure, and general metabolism. However, excessive mitochondrial fusion or fission results in the disruption of the skeletal muscle mitochondrial network integrity and activates a retrograde response from mitochondria to the nucleus, leading to muscle atrophy, weakness and influencing whole-body homeostasis. These actions are mediated via the secretion of mitochondrial-stress myokines such as FGF21 and GDF15. Here we will summarize recent discoveries in the role of mitochondrial fusion and fission in the control of muscle mass and in regulating physiological homeostasis and disease progression.

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线粒体融合和裂变对骨骼肌质量和健康的影响
融合和裂变事件对线粒体的持续动态重塑对于控制线粒体的质量和功能以应对能量和压力的变化至关重要。维持一个功能性的、高度互联的线粒体网确保了能量的快速产生和分配。此外,线粒体网络充当动态信号中枢,以适应收缩、能量消耗和一般代谢带来的代谢需求。然而,过度的线粒体融合或分裂会导致骨骼肌线粒体网络完整性的破坏,并激活从线粒体到细胞核的逆行反应,导致肌肉萎缩、虚弱并影响全身稳态。这些作用是通过线粒体应激性肌细胞因子如FGF21和GDF15的分泌介导的。在这里,我们将总结线粒体融合和分裂在控制肌肉质量、调节生理稳态和疾病进展中的作用的最新发现。
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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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