Pandemic response strategies and threshold phenomena

Pieter Streicher , Alex Broadbent
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Abstract

This paper critically evaluates the Suppression Threshold Strategy (STS) for controlling Covid-19 (C-19). STS asserts a “fundamental distinction” between suppression and mitigation strategies, reflected in very different outcomes in eventual mortality depending on whether reproductive number R is caused to fall below 1. We show that there is no real distinction based on any value of R which falls in any case from early on in an epidemic wave. We show that actual mortality outcomes lay on a continuum, correlating with suppression levels, but not exhibiting any step changes or threshold effects. We argue that an excessive focus on achieving suppression at all costs, driven by the erroneous notion that suppression is a threshold, led to a lack of information on how to trade off the effects of different specific interventions. This led many countries to continue with inappropriate intervention-packages even after it became clear that their initial goal was not going to be attained. Future pandemic planning must support the design of “Plan B", which may be quite different from “Plan A".

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流行病应对策略和阈值现象
本文对控制新冠肺炎(C-19)的抑制阈值策略(STS)进行了批判性评估。STS声称,抑制和缓解策略之间存在“根本区别”,这反映在最终死亡率的不同结果上,这取决于生殖数R是否降至1以下。我们表明,在任何情况下,从流行病浪潮的早期开始,R的任何值都没有真正的区别。我们发现,实际的死亡率结果是连续的,与抑制水平相关,但没有表现出任何阶跃变化或阈值效应。我们认为,由于压制是一个门槛的错误观念,过度关注不惜一切代价实现压制,导致缺乏关于如何权衡不同具体干预措施效果的信息。这导致许多国家即使在其最初的目标显然无法实现之后,仍继续采取不适当的一揽子干预措施。未来的疫情规划必须支持“B计划”的设计,这可能与“A计划”截然不同。
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来源期刊
Global Epidemiology
Global Epidemiology Medicine-Infectious Diseases
CiteScore
5.00
自引率
0.00%
发文量
22
审稿时长
39 days
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