Spatial and non-spatial feature binding impairments in visual working memory in schizophrenia

IF 2.3 Q2 PSYCHIATRY Schizophrenia Research-Cognition Pub Date : 2023-06-01 DOI:10.1016/j.scog.2023.100281
Antigoni Belekou , Mohammad Zia Ul Haq Katshu , Neil Michael Dundon , Giovanni d'Avossa , Nikolaos Smyrnis
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引用次数: 1

Abstract

Working memory (WM) impairments are well recognized in schizophrenia patients (PSZ) and contribute to poor psycho-social outcomes in this population. Distinct neural networks underlay the ability to encode and recall visual and spatial information raising the possibility that profile of visual working memory performance may help pinpoint dysfunctional neural correlates in schizophrenia. This study assessed the resolution and associative aspects of visual working memory deficits in schizophrenia and whether these deficits arise during encoding or maintenance processes. A total of 60 participants (30 PSZ and 30 healthy controls) matched in age, gender and education assessed on a modified object in place (OiPT), a delayed non-match-to-sample (DNMST) and a delayed spatial estimation (DSET) task. Patients demonstrated lower accuracy than controls in binding visual features of the same object and recognizing novel objects as well as lower precision recalling the location of a memorized target. Moreover, response choice set size affected recognition accuracy more in PSZ than controls. However, delay duration affected spatial recall precisions, binding, and recognition accuracy equally in the two groups. Our results suggest that visual working memory (vWM) impairments in schizophrenia predominantly reflect spatial and non-spatial binding deficits, with largely preserved discrete feature information. Moreover, these impairments likely arise more during encoding than during maintenance. These binding deficits may reflect impaired effective neural functional connectivity observed in schizophrenia.

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精神分裂症患者视觉工作记忆的空间和非空间特征结合障碍
工作记忆(WM)障碍在精神分裂症患者(PSZ)中得到了很好的识别,并导致该人群的不良心理社会结果。独特的神经网络具有编码和回忆视觉和空间信息的能力,这增加了视觉工作记忆表现的特征可能有助于确定精神分裂症中功能失调的神经相关性的可能性。这项研究评估了精神分裂症患者视觉工作记忆缺陷的分辨率和联想方面,以及这些缺陷是否发生在编码或维持过程中。共有60名参与者(30名PSZ和30名健康对照)在年龄、性别和教育程度上匹配,评估了一项改良的原地对象(OiPT)、一项延迟不匹配样本(DNMST)和一项延迟空间估计(DSET)任务。与对照组相比,患者在绑定同一物体的视觉特征和识别新物体方面表现出较低的准确性,以及回忆记忆目标位置的精度较低。此外,与对照组相比,PSZ中的响应选择集大小对识别精度的影响更大。然而,延迟时间对两组的空间回忆精度、绑定和识别精度的影响相同。我们的研究结果表明,精神分裂症患者的视觉工作记忆(vWM)损伤主要反映了空间和非空间结合缺陷,并在很大程度上保留了离散特征信息。此外,这些损伤可能在编码期间比在维护期间出现得更多。这些结合缺陷可能反映了在精神分裂症中观察到的有效神经功能连接受损。
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来源期刊
CiteScore
5.60
自引率
10.70%
发文量
54
审稿时长
67 days
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