Spatial and non-spatial feature binding impairments in visual working memory in schizophrenia

IF 2.3 Q2 PSYCHIATRY Schizophrenia Research-Cognition Pub Date : 2023-06-01 DOI:10.1016/j.scog.2023.100281
Antigoni Belekou , Mohammad Zia Ul Haq Katshu , Neil Michael Dundon , Giovanni d'Avossa , Nikolaos Smyrnis
{"title":"Spatial and non-spatial feature binding impairments in visual working memory in schizophrenia","authors":"Antigoni Belekou ,&nbsp;Mohammad Zia Ul Haq Katshu ,&nbsp;Neil Michael Dundon ,&nbsp;Giovanni d'Avossa ,&nbsp;Nikolaos Smyrnis","doi":"10.1016/j.scog.2023.100281","DOIUrl":null,"url":null,"abstract":"<div><p>Working memory (WM) impairments are well recognized in schizophrenia patients (PSZ) and contribute to poor psycho-social outcomes in this population. Distinct neural networks underlay the ability to encode and recall visual and spatial information raising the possibility that profile of visual working memory performance may help pinpoint dysfunctional neural correlates in schizophrenia. This study assessed the resolution and associative aspects of visual working memory deficits in schizophrenia and whether these deficits arise during encoding or maintenance processes. A total of 60 participants (30 PSZ and 30 healthy controls) matched in age, gender and education assessed on a modified object in place (OiPT), a delayed non-match-to-sample (DNMST) and a delayed spatial estimation (DSET) task. Patients demonstrated lower accuracy than controls in binding visual features of the same object and recognizing novel objects as well as lower precision recalling the location of a memorized target. Moreover, response choice set size affected recognition accuracy more in PSZ than controls. However, delay duration affected spatial recall precisions, binding, and recognition accuracy equally in the two groups. Our results suggest that visual working memory (vWM) impairments in schizophrenia predominantly reflect spatial and non-spatial binding deficits, with largely preserved discrete feature information. Moreover, these impairments likely arise more during encoding than during maintenance. These binding deficits may reflect impaired effective neural functional connectivity observed in schizophrenia.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"32 ","pages":"Article 100281"},"PeriodicalIF":2.3000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/5c/main.PMC9930192.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Schizophrenia Research-Cognition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2215001323000045","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 1

Abstract

Working memory (WM) impairments are well recognized in schizophrenia patients (PSZ) and contribute to poor psycho-social outcomes in this population. Distinct neural networks underlay the ability to encode and recall visual and spatial information raising the possibility that profile of visual working memory performance may help pinpoint dysfunctional neural correlates in schizophrenia. This study assessed the resolution and associative aspects of visual working memory deficits in schizophrenia and whether these deficits arise during encoding or maintenance processes. A total of 60 participants (30 PSZ and 30 healthy controls) matched in age, gender and education assessed on a modified object in place (OiPT), a delayed non-match-to-sample (DNMST) and a delayed spatial estimation (DSET) task. Patients demonstrated lower accuracy than controls in binding visual features of the same object and recognizing novel objects as well as lower precision recalling the location of a memorized target. Moreover, response choice set size affected recognition accuracy more in PSZ than controls. However, delay duration affected spatial recall precisions, binding, and recognition accuracy equally in the two groups. Our results suggest that visual working memory (vWM) impairments in schizophrenia predominantly reflect spatial and non-spatial binding deficits, with largely preserved discrete feature information. Moreover, these impairments likely arise more during encoding than during maintenance. These binding deficits may reflect impaired effective neural functional connectivity observed in schizophrenia.

Abstract Image

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
精神分裂症患者视觉工作记忆的空间和非空间特征结合障碍
工作记忆(WM)障碍在精神分裂症患者(PSZ)中得到了很好的识别,并导致该人群的不良心理社会结果。独特的神经网络具有编码和回忆视觉和空间信息的能力,这增加了视觉工作记忆表现的特征可能有助于确定精神分裂症中功能失调的神经相关性的可能性。这项研究评估了精神分裂症患者视觉工作记忆缺陷的分辨率和联想方面,以及这些缺陷是否发生在编码或维持过程中。共有60名参与者(30名PSZ和30名健康对照)在年龄、性别和教育程度上匹配,评估了一项改良的原地对象(OiPT)、一项延迟不匹配样本(DNMST)和一项延迟空间估计(DSET)任务。与对照组相比,患者在绑定同一物体的视觉特征和识别新物体方面表现出较低的准确性,以及回忆记忆目标位置的精度较低。此外,与对照组相比,PSZ中的响应选择集大小对识别精度的影响更大。然而,延迟时间对两组的空间回忆精度、绑定和识别精度的影响相同。我们的研究结果表明,精神分裂症患者的视觉工作记忆(vWM)损伤主要反映了空间和非空间结合缺陷,并在很大程度上保留了离散特征信息。此外,这些损伤可能在编码期间比在维护期间出现得更多。这些结合缺陷可能反映了在精神分裂症中观察到的有效神经功能连接受损。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
5.60
自引率
10.70%
发文量
54
审稿时长
67 days
期刊最新文献
Cognitive functioning and functional ability in women with schizophrenia and homelessness Humor processing and its relationship with clinical features in patients with first-episode schizophrenia Through the lens of schizophrenia: Recognizing negative facial expressions and family patterns Transcranial direct current stimulation and its effect on cognitive symptoms of schizophrenia: An updated review Advances in the ecological validity of research on social cognition in schizophrenia: A systematic review of the literature
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1