Limited host availability disrupts the genetic correlation between virulence and transmission.

IF 3.4 1区生物学 Q2 EVOLUTIONARY BIOLOGY Evolution Letters Pub Date : 2023-01-31 eCollection Date: 2023-02-01 DOI:10.1093/evlett/qrac008

Diogo P Godinho, Leonor R Rodrigues, Sophie Lefèvre, Laurane Delteil, André F Mira, Inês R Fragata, Sara Magalhães, Alison B Duncan

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Abstract

Virulence is expected to be linked to parasite fitness via transmission. However, it is not clear whether this relationship is genetically determined, nor if it differs when transmission occurs continuously during, or only at the end of, the infection period. Here, we used inbred lines of the macroparasitic spider mite Tetranychus urticae to disentangle genetic vs. nongenetic correlations among traits, while varying parasite density and opportunities for transmission. A positive genetic correlation between virulence and the number of transmitting stages produced was found under continuous transmission. However, if transmission occurred only at the end of the infection period, this genetic correlation disappeared. Instead, we observed a negative relationship between virulence and the number of transmitting stages, driven by density dependence. Thus, within-host density dependence caused by reduced opportunities for transmission may hamper selection for higher virulence, providing a novel explanation as to why limited host availability leads to lower virulence.

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有限的宿主可利用性破坏了毒力和传播之间的遗传相关性。

预计病毒通过传播与寄生虫的健康状况有关。然而，目前尚不清楚这种关系是否是由基因决定的，也不清楚在感染期内或仅在感染期结束时传播是否不同。在这里，我们使用了大寄生蜘蛛螨二氏叶螨的近交系来理清性状之间的遗传与非遗传相关性，同时改变寄生虫密度和传播机会。在连续传播的情况下，毒力与产生的传播阶段数之间存在正的遗传相关性。然而，如果传播只发生在感染期结束时，这种遗传相关性就会消失。相反，我们观察到毒力与传播阶段数量之间存在负相关，这是由密度依赖性驱动的。因此，由传播机会减少引起的宿主内密度依赖性可能会阻碍对更高毒力的选择，这为为什么有限的宿主可用性导致更低的毒力提供了新的解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Evolution Letters EVOLUTIONARY BIOLOGY-

CiteScore

13.00

自引率

2.00%

发文量

审稿时长

10 weeks

期刊介绍： Evolution Letters publishes cutting-edge new research in all areas of Evolutionary Biology. Available exclusively online, and entirely open access, Evolution Letters consists of Letters - original pieces of research which form the bulk of papers - and Comments and Opinion - a forum for highlighting timely new research ideas for the evolutionary community.