Genome-wide association study of handgrip strength in the Northern Chinese adult twins.

IF 2.8 4区医学 Q3 CELL BIOLOGY Connective Tissue Research Pub Date : 2023-03-01 DOI:10.1080/03008207.2022.2104160

Jia Luo, Tianhao Zhang, Weijing Wang, Dongfeng Zhang

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引用次数: 1

Abstract

Purpose: Currently, new loci related to handgrip strength have been identified in genome-wide association studies. However, this topic is an understudied area in the Chinese population.

Materials and methods: A total of 135 dizygotic twin pairs recruited from the Qingdao Twin Registry system were included in the present study. Using GEMMA, VEAGSE2, and PASCAL software for SNP-based analysis, gene-based analysis, and pathway-based analysis, respectively. The resulting SNPs were subjected to eQTL analysis.

Results: Although none of the loci reach the statistically significant level (p < 5 × 10^-8), we found 19 SNPs exceeding the suggestive significant level (p < 1 × 10^-5). After imputation, 162 SNPs reached suggestive evidence level for handgrip strength. A total of 1,118 genes reached the nominal significance level (p < 0.05) in gene-based analysis. A total of 626 potential biological pathways were associated with handgrip strength (p < 0.05). The results of eQTL analysis were mainly enriched in tissues such as the muscle-skeletal, brain, visceral fat, and brain-cortical.

Conclusions: Genetic variants may involve in regulatory domains, functional genes, and biological pathways that mediate handgrip strength.

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中国北方成年双胞胎握力的全基因组关联研究。

目的:目前，在全基因组关联研究中发现了与握力相关的新位点。然而，这个话题在中国人口中是一个研究不足的领域。材料与方法:本研究从青岛双胞胎登记系统中招募了135对异卵双胞胎。分别使用GEMMA、VEAGSE2和PASCAL软件进行snp分析、基因分析和通路分析。所得snp进行eQTL分析。结果:虽然没有一个位点达到统计学显著水平(p -8)，但我们发现19个snp超过了提示显著水平(p -5)。计算后，162个snp达到了握力的暗示证据水平。共有1118个基因达到名义显著性水平(p p)。结论:遗传变异可能涉及调节握力的调控域、功能基因和生物学途径。

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来源期刊

Connective Tissue Research 生物-细胞生物学

CiteScore

6.60

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： The aim of Connective Tissue Research is to present original and significant research in all basic areas of connective tissue and matrix biology. The journal also provides topical reviews and, on occasion, the proceedings of conferences in areas of special interest at which original work is presented. The journal supports an interdisciplinary approach; we present a variety of perspectives from different disciplines, including Biochemistry Cell and Molecular Biology Immunology Structural Biology Biophysics Biomechanics Regenerative Medicine The interests of the Editorial Board are to understand, mechanistically, the structure-function relationships in connective tissue extracellular matrix, and its associated cells, through interpretation of sophisticated experimentation using state-of-the-art technologies that include molecular genetics, imaging, immunology, biomechanics and tissue engineering.