Chinedu A Ezekekwu, Taiwo R Kotila, Titilola S Akingbola, Guillaume Lettre, Victor R Gordeuk, Richard S Cooper, Michael R DeBaun, Baba Inusa, Bamidele O Tayo
{"title":"Sickle Cell Disease Clinical Trials and Phenotypes.","authors":"Chinedu A Ezekekwu, Taiwo R Kotila, Titilola S Akingbola, Guillaume Lettre, Victor R Gordeuk, Richard S Cooper, Michael R DeBaun, Baba Inusa, Bamidele O Tayo","doi":"10.4172/2329-891X.1000259","DOIUrl":null,"url":null,"abstract":"<p><p>Sickle cell disease, one of the world's most common genetic disorders is prevalent in sub-Saharan Africa. The trans-Atlantic slave trade accounted for the gene movement from Africa to the Caribbean and United States of America and lately, migration has resulted in the introduction of the gene to the United Kingdom and other parts of Europe. Different haplotypes exist, however the differences in these haplotypes are not sufficient to explain the different clinical variations within the same region or different settings.</p>","PeriodicalId":74002,"journal":{"name":"Journal of tropical diseases & public health","volume":"6 2","pages":"259"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2329-891X.1000259","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of tropical diseases & public health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2329-891X.1000259","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Sickle cell disease, one of the world's most common genetic disorders is prevalent in sub-Saharan Africa. The trans-Atlantic slave trade accounted for the gene movement from Africa to the Caribbean and United States of America and lately, migration has resulted in the introduction of the gene to the United Kingdom and other parts of Europe. Different haplotypes exist, however the differences in these haplotypes are not sufficient to explain the different clinical variations within the same region or different settings.
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