Determination, exposure and risk assessment of PAHs in natural vitamin E isolated from vegetable oil industry.

IF 2.5 3区农林科学 Q2 CHEMISTRY, APPLIED Food additives & contaminants. Part B, Surveillance Pub Date : 2023-06-01 DOI:10.1080/19393210.2023.2182833

Guangyi Gong, Shimin Wu

引用次数: 0

Abstract

Natural vitamin E, which is mainly extracted from vegetable oil deodoriser distillate (VODD), is likely contaminated by carcinogenic polycyclic aromatic hydrocarbons (PAHs). A total of 26 commercial vitamin E products from six countries were investigated for 16 EPA PAHs using QuEChERS combined with gas chromatography triple quadrupole mass spectrometry (GC-QQQ-MS). The concentrations of total PAHs in the samples ranged from 46.5 μg kg^-1 to 215 μg kg^-1, while the concentrations of PAH4 (BaA, Chr, BbF and BaP) ranged from 4.43 μg kg^-1 to 20.1 μg kg^-1. Risk assessment indicates that maximum intake of PAHs is 0.2 mg day^-1, which is less than the LD₅₀ and no observed adverse effect levels (NOAEL) of PAHs. However, chronic carcinogenicity of PAHs needs to be considered. The results suggested that PAH concentrations as well as toxicity equivalent should be considered as important indicator of risk of vitamin E products.

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植物油工业天然维生素E中多环芳烃的测定、暴露及风险评估。

天然维生素E主要从植物油脱臭馏出物(VODD)中提取，可能受到致癌物多环芳烃(PAHs)的污染。采用QuEChERS联合气相色谱-三重四极杆质谱(GC-QQQ-MS)对来自6个国家的26种商业维生素E产品进行了16种EPA多环芳烃的检测。样品中总PAHs浓度在46.5 ~ 215 μ kg-1之间，PAH4 (BaA、Chr、BbF和BaP)浓度在4.43 ~ 20.1 μ kg-1之间。风险评估显示，多环芳烃的最大摄入量为0.2 mg d -1，小于LD50，未观察到多环芳烃的不良影响水平(NOAEL)。然而，多环芳烃的慢性致癌性需要考虑。结果表明，多环芳烃浓度和毒性当量应作为维生素E产品风险的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food additives & contaminants. Part B, Surveillance 农林科学-毒理学

CiteScore

5.30

自引率

10.30%

发文量

审稿时长

2.7 months

期刊介绍： Food Additives & Contaminants: Part B publishes surveillance data indicating the presence and levels of occurrence of designated food additives, residues and contaminants in foods, food supplements and animal feed. Data using validated methods must meet stipulated quality standards to be acceptable and must be presented in a prescribed format for subsequent data-handling. Food Additives & Contaminants: Part B restricts its scope to include certain classes of food additives, residues and contaminants. This is based on a goal of covering those areas where there is a need to record surveillance data for the purposes of exposure and risk assessment. The scope is initially restricted to: Additives - food colours, artificial sweeteners, and preservatives; Residues – veterinary drug and pesticide residues; Contaminants – metals, mycotoxins, phycotoxins, plant toxins, nitrate/nitrite, PCDDs/PCFDs, PCBs, PAHs, acrylamide, 3-MPCD and contaminants derived from food packaging. Readership: The readership includes scientists involved in all aspects of food safety and quality and particularly those involved in monitoring human exposure to chemicals from the diet. Papers reporting surveillance data in areas other than the above should be submitted to Part A . The scope of Part B will be expanded from time-to-time to ensure inclusion of new areas of concern.