DNA methylation signatures as biomarkers of socioeconomic position.

IF 4.8 Q1 GENETICS & HEREDITY Environmental Epigenetics Pub Date : 2022-12-14 eCollection Date: 2023-01-01 DOI:10.1093/eep/dvac027

Meghna Rajaprakash, Lorraine T Dean, Meredith Palmore, Sara B Johnson, Joan Kaufman, Daniele M Fallin, Christine Ladd-Acosta

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Abstract

This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between individual- and neighborhood-level SEP exposures and DNAm across the life course. In contrast to questionnaire-based methods of assessing SEP, we suggest that DNAm biomarkers may offer an accessible metric to study questions about SEP and health outcomes, acting as a personal dosimeter of exposure. However, further work remains in standardizing SEP measures across studies and evaluating consistency across domains, tissue types, and time periods. Meta-analyses of epigenetic associations with SEP are offered as one approach to confirm the replication of DNAm loci across studies. The development of DNAm biomarkers of SEP would provide a method for examining its impact on health outcomes in a more robust way, increasing the rigor of epidemiological studies.

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DNA甲基化特征作为社会经济地位的生物标志物。

这篇综述文章为使用脱氧核糖核酸（DNA）甲基化（DNAm）生物标志物研究社会经济地位（SEP）的生物嵌入提供了一个框架，并总结了该领域的最新进展。它介绍了新出现的文献，显示了个人和社区水平的SEP暴露与整个生命过程中的DNAm之间的关联。与基于问卷的SEP评估方法相反，我们认为DNAm生物标志物可以作为个人暴露剂量计，为研究SEP和健康结果的问题提供一个可访问的指标。然而，在标准化各研究的SEP测量以及评估各领域、组织类型和时间段的一致性方面，仍有进一步的工作要做。表观遗传学与SEP关联的荟萃分析是确认DNAm基因座在研究中复制的一种方法。SEP的DNAm生物标志物的开发将提供一种更有力的方法来检查其对健康结果的影响，从而提高流行病学研究的严谨性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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