Delay modulates the immune response to nerve repair.

IF 6.4 1区 医学 Q1 CELL & TISSUE ENGINEERING npj Regenerative Medicine Pub Date : 2023-02-27 DOI:10.1038/s41536-023-00285-4
Masoud Golshadi, Elaine F Claffey, Jennifer K Grenier, Andrew Miller, Michael Willand, Michael G Edwards, Tim P Moore, Michael Sledziona, Tessa Gordon, Gregory H Borschel, Jonathan Cheetham
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Abstract

Effective regeneration after peripheral nerve injury requires macrophage recruitment. We investigated the activation of remodeling pathways within the macrophage population when repair is delayed and identified alteration of key upstream regulators of the inflammatory response. We then targeted one of these regulators, using exogenous IL10 to manipulate the response to injury at the repair site. We demonstrate that this approach alters macrophage polarization, promotes macrophage recruitment, axon extension, neuromuscular junction formation, and increases the number of regenerating motor units reaching their target. We also demonstrate that this approach can rescue the effects of delayed nerve graft.

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延迟调节神经修复的免疫反应。
周围神经损伤后的有效再生需要巨噬细胞的招募。我们研究了修复延迟时巨噬细胞群内重塑通路的激活情况,并确定了炎症反应上游关键调节因子的改变。然后,我们针对其中一个调节因子,使用外源性 IL10 来操纵修复部位的损伤反应。我们证明,这种方法改变了巨噬细胞的极化,促进了巨噬细胞的招募、轴突的延伸、神经肌肉接头的形成,并增加了到达目标的再生运动单位的数量。我们还证明,这种方法可以挽救延迟神经移植的效果。
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来源期刊
npj Regenerative Medicine
npj Regenerative Medicine Engineering-Biomedical Engineering
CiteScore
10.00
自引率
1.40%
发文量
71
审稿时长
12 weeks
期刊介绍: Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.
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