Aldehyde dehydrogenase 2 polymorphism is an important gene for insulin resistance in Japanese patients with type 2 diabetes

Metabolism open Pub Date : 2023-06-01 DOI:10.1016/j.metop.2023.100242

Tsuyoshi Okura , Risa Nakamura , Mari Anno , Yuichi Ito , Sonoko Kitao , Satomi Endo , Natsuka Taneda , Kazuhisa Matsumoto , Kyoko Shoji , Hiroko Okura , Kazuhiko Matsuzawa , Shoichiro Izawa , Etsuko Ueta , Masahiko Kato , Takeshi Imamura , Shin-ichi Taniguchi , Kazuhiro Yamamoto

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Abstract

Background

Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme involved in alcohol metabolism. ALDH2 polymorphism has been reported as a risk factor for type 2 diabetes mellitus (T2DM) and is associated with liver insulin resistance due to alcohol consumption in non-diabetic individuals. Herein, we investigated the association between ALDH2 polymorphisms and insulin resistance in patients with T2DM.

Methods

We performed a meal tolerance test and the hyperinsulinemic-euglycemic clamp on 71 Japanese participants: 34 patients with T2DM, and 37 non-diabetic participants. We analyzed the ALDH2 polymorphism (ALDH2 rs67); GG type was defined as the T2DM high-risk group, compared with the low-risk AG and AA groups.

Results

Glucose levels were similar in the high- and low-risk T2DM groups. The high-risk group for T2DM showed a significantly higher BMI (p < 0.005), insulin resistance in HOMA-IR (p < 0.05), and Insulin sensitivity index (p < 0.05); however, there were no significant differences in insulin resistance in the clamp test (p = 0.10). Alcohol consumption did not differ significantly between groups (p = 0.66). Non-diabetic participants also showed higher HOMA-IR insulin resistance in the high-risk group (p < 0.05), but insulin resistance levels in the glucose clamp tests (p = 0.56) and insulin secretion were not significant.

Conclusion

The results suggest that ALDH2 is an important gene associated with insulin resistance and obesity in Japanese patients with type 2 diabetes.

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乙醛脱氢酶2多态性是日本2型糖尿病患者胰岛素抵抗的重要基因

背景乙醛脱氢酶2（ALDH2）是参与酒精代谢的重要酶。ALDH2多态性已被报道为2型糖尿病（T2DM）的危险因素，并与非糖尿病患者饮酒引起的肝胰岛素抵抗有关。在此，我们研究了ALDH2多态性与T2DM患者胰岛素抵抗之间的关系。方法我们对71名日本参与者进行了膳食耐受性测试和高胰岛素-正常血糖钳夹：34名T2DM患者和37名非糖尿病参与者。我们分析了ALDH2多态性（ALDH2-rs67）；GG型被定义为T2DM高危组，与低危AG和AA组相比。结果2型糖尿病高危组和低危组血糖水平相似。T2DM高危组表现出显著更高的BMI（p＜0.005）、HOMA-IR中的胰岛素抵抗（p＜0.05）和胰岛素敏感性指数（p＜0.01）；然而，钳夹试验中的胰岛素抵抗没有显著差异（p=0.10）。各组之间的饮酒量没有显著差别（p=0.66）。非糖尿病参与者在高危组中也表现出更高的HOMA-IR胰岛素抵抗（p<；0.05），但葡萄糖钳夹试验中的胰岛素抵抗水平（p＝0.56）和胰岛素分泌并不显著。结论ALDH2是日本2型糖尿病患者胰岛素抵抗和肥胖的重要基因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metabolism open Agricultural and Biological Sciences (General), Endocrinology, Endocrinology, Diabetes and Metabolism

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40 days