Metabolism open最新文献

{"title":"Investigating the causal roles of cholesterol and triglyceride subfractions across lipoproteins in irritable bowel syndrome: a Mendelian randomization study","authors":"Fang Peng ,&nbsp;Kemin Xu ,&nbsp;Qinwen Ba ,&nbsp;Hao Bi ,&nbsp;Yanjun Lu","doi":"10.1016/j.metop.2025.100434","DOIUrl":"10.1016/j.metop.2025.100434","url":null,"abstract":"<div><h3>Background</h3><div>Dietary composition and nutrient intake are increasingly recognised as key modulators of symptom onset and severity in a substantial subset of patients with irritable bowel syndrome (IBS). Among dietary lipids, cholesterol and triglycerides have emerged as potential contributors. Nevertheless, the causal relationship remains poorly understood, and evidence in this area remains limited. To address this gap, we conducted a Mendelian randomization (MR) study to dissect the putative causal effects of cholesterol and triglycerides on IBS risk in individuals of European ancestry.</div></div><div><h3>Methods</h3><div>Instrumental variables were constructed for 17 lipid traits—total cholesterol, free cholesterol, triglycerides, and 13 size-specific High-density lipoprotein(HDL), Low-density lipoprotein(LDL), and Very low-density lipoprotein (VLDL) sub-fractions—using summary-level data from the largest available genome-wide association studies (GWAS). Lipid exposures were derived from a meta-analysis of 115,082 European-ancestry individuals. IBS outcomes were ascertained in an independent cohort of 486,601 participants of European descent. Causal estimates were obtained with five complementary MR methods: inverse-variance weighted (IVW), weighted median, MR-Egger, simple mode, and weighted mode. Robustness was further interrogated with leave-one-out permutation, MR-Egger intercept evaluation of directional pleiotropy, and Cochran's Q assessment of heterogeneity.</div></div><div><h3>Results</h3><div>The MR analysis indicated that cholesterol or free cholesterol content of chylomicrons and extremely large VLDL particles were causally associated with an increased risk of developing IBS (β = 0.0679, odds ratios (OR) = 1.070, 95 % CI 1.015–1.128, P = 0.0118; and β = 0.0650, OR = 1.0672, 95 % CI 1.0179–1.1189, P = 0.0007, respectively). Conversely, equivalent increments in cholesterol or free cholesterol carried by very large HDL or very small VLDL conferred protection (β = −0.0626, OR = 0.9392, 95 % CI 0.8992–0.9810, P = 0.0047; and β = -0.0604, OR = 0.9412, 95 % CI 0.9023–0.9819, P = 0.005). Total circulating triglycerides also displayed a positive causal effect on IBS susceptibility (β = 0.0798, OR = 1.083, 95 % CI 1.0268–1.1423, P = 0.0033), with concordant directional estimates observed across the majority of lipoprotein sub-fractions.</div></div><div><h3>Conclusion</h3><div>Whereas triglycerides conveyed a uniformly adverse effect on IBS risk regardless of lipoprotein carrier, cholesterol displayed a net protective signal across most particle classes. This dichotomy implies that lipid-centred interventions should discriminate between the two moieties: dietary or pharmacological strategies that selectively lower triglycerides while preserving—or even augmenting—cholesterol in specific lipoprotein fractions may offer a rational, mechanistically grounded approach to IBS prevention and management.</div></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"29 ","pages":"Article 100434"},"PeriodicalIF":2.7,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a multidisciplinary “2+N system therapy” in achieving remission and metabolic improvement in type 2 diabetes: A real-world study with 1,000 patients","authors":"Kejing Zeng ,&nbsp;Bo Chen ,&nbsp;Hejun Li ,&nbsp;Nina Ren ,&nbsp;Yingying Song ,&nbsp;Minlin Liang ,&nbsp;Yin Yang ,&nbsp;Yali Huang ,&nbsp;Ting Liu ,&nbsp;Yiguang Lin ,&nbsp;Gugen Xu","doi":"10.1016/j.metop.2025.100436","DOIUrl":"10.1016/j.metop.2025.100436","url":null,"abstract":"<div><h3>Background</h3><div>Type 2 diabetes mellitus (T2DM) is a major global health challenge characterized by insulin resistance and β-cell dysfunction. Traditional treatments often fail to achieve sustained remission. This study evaluated a comprehensive “2 + N system therapy” combining Western and traditional Chinese medicine (TCM) with individualized lifestyle interventions to promote T2DM remission and improve metabolic health.</div></div><div><h3>Methods</h3><div>In a real-world observational study, 1000 T2DM patients (disease duration ≤5 years; BMI ≥24 kg/m² or elevated waist circumference; preserved C-peptide) were treated with 2 + N therapy at Guangdong Second Provincial General Hospital (2015–2022). The “2” phase involved intensive insulin therapy transitioning to non-insulin agents with tailored TCM; the “N” phase included calorie-restricted low-carbohydrate diet, exercise, and psychological support. Primary outcome was diabetes remission (HbA₁c &lt; 6.5 % for ≥3 months without medication). Secondary outcomes included changes in weight, BMI, waist/hip circumference, glycemic indices, insulin resistance (HOMA-IR), β-cell function (HOMA-β), lipids, uric acid, and MRI-assessed hepatic and pancreatic fat in a subset.</div></div><div><h3>Results</h3><div>At 6 months, 70.5 % of participants achieved remission. Significant metabolic improvements were observed, including mean weight reduction (9.2 ± 4.3 kg), BMI decrease (3.2 ± 1.4 kg/m²), waist circumference reduction (11.0 ± 4.2 cm), and notable improvements in glycemic control (HbA₁c decreased from 7.3 ± 1.3 % to 5.3 ± 0.4 %). Lipid profiles significantly improved, with triglycerides declining from 6.34 ± 3.25 to 1.39 ± 0.95 mmol/L and total cholesterol from 7.41 ± 2.20 to 3.76 ± 0.86 mmol/L. MRI analysis of a subgroup (n = 26) showed significant reductions in hepatic fat (28.8 %) and pancreatic fat (25.0 %).</div></div><div><h3>Conclusions</h3><div>The “2+N system therapy” demonstrated a high remission rate and extensive metabolic benefits, including substantial weight loss, improved glycemic control, enhanced insulin sensitivity, and reductions in ectopic fat. However, causality cannot be established without a control group and further prospective controlled trials are required to confirm its efficacy.</div></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"29 ","pages":"Article 100436"},"PeriodicalIF":2.7,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No effect of pyrroloquinoline quinone on mouse body weight and energy metabolism with the concomitant increase in mitochondrial biogenesis and antioxidant ability","authors":"Lijun Zhang ,&nbsp;Yimin Xu ,&nbsp;Yanyan Zhao ,&nbsp;Xiaochun Zhang ,&nbsp;Xiangyan Liang ,&nbsp;Zhuo Sun ,&nbsp;Ying Zhou ,&nbsp;Huan Liu ,&nbsp;Jinrui Chang ,&nbsp;Man Shi ,&nbsp;Yufeng Zhao","doi":"10.1016/j.metop.2025.100433","DOIUrl":"10.1016/j.metop.2025.100433","url":null,"abstract":"<div><div>Pyrroloquinoline quinone (PQQ) stimulates mitochondrial biogenesis and exhibits antioxidant properties. Since mitochondria play a crucial role in energy generation and metabolism, the present study aims to clarify whether PQQ is able to modulate energy expenditure and the development of obesity by regulating mitochondrial biogenesis. Male mice fed normal chow diet (NCD) or high fat diet (HFD) were supplemented with PQQ through drinking water for three months. Throughout this period, food and water intake, body weight, energy metabolic rate and the autonomous activity of the mice were measured. Then, the mice were sacrificed and the tissues were collected. Mitochondrial biogenesis, antioxidant capacity, and changes in gene expression were measured in liver tissue. The results showed that PQQ supplementation did not result in significant alterations in the food and water intake, body weight, and energy metabolic rate of the mice fed NCD or HFD although it significantly enhanced mitochondrial biogenesis and antioxidant capabilities of liver and promoted autonomous activity in NCD mice. Moreover, it had no impact on the adipose tissue mass in mice fed NCD or HFD. While PQQ supplementation induced the changes in metabolism-related genes such as CPT1a, SCD1, FABP1, HK2, HK3 and PGK1 in liver, it is suggested PQQ supplementation may influence lipid and glucose metabolism. However, PQQ-induced changes in hepatic gene expression and mitochondrial biogenesis are unable to alter systemic energy metabolism and adipose tissue accumulation in male mice.</div></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"29 ","pages":"Article 100433"},"PeriodicalIF":2.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a virtual Culinary medicine curriculum on fatty acid profiles in medical students","authors":"Selina Böttcher ,&nbsp;Thomas Ellrott ,&nbsp;Miriam Rabehl ,&nbsp;Can G. Leineweber ,&nbsp;Chaoxuan Wang ,&nbsp;Uwe Neumann ,&nbsp;Anne Pietzner ,&nbsp;Christoph Schmöcker ,&nbsp;Karsten H. Weylandt","doi":"10.1016/j.metop.2025.100431","DOIUrl":"10.1016/j.metop.2025.100431","url":null,"abstract":"<div><h3>Background</h3><div>Culinary Medicine (CM) has gained increasing popularity as an educational approach to improve nutrition-related competencies among healthcare professionals. Previous studies have demonstrated increased counseling competencies, but also improvements in dietary behaviors among participants, however, objective biomarker-based evidence of such behavioral changes remains scarce. This pilot study aimed to explore preliminary effects of a CM course on biochemical and anthropometric parameters, and to evaluate the feasibility of biomarker assessment among medical students.</div></div><div><h3>Methods</h3><div>In this exploratory pre-post study, medical students completed a 20-h virtual CM curriculum. Blood samples were collected before and after the course to assess lipid parameters, HbA1c, erythrocyte fatty acid compositions, and body weight.</div></div><div><h3>Results</h3><div>Of 30 enrolled students, 13 participated in the biomarker assessment. There were slight non-significant decreases in Body Mass Index (−0.08 kg/m², <em>p</em> = 0.07) and standard laboratory lipid parameters, including LDL Cholesterol (−0.08 mmol/L, <em>p</em> = 0.598) and total cholesterol (−0.12 mmol/L, <em>p</em> = 0.493). Significant alterations in erythrocyte fatty acids were detected with a slight increase in saturated fatty acids (+0.78 %, <em>p</em> = 0.004) and, in particular, monounsaturated fatty acids (+1.04 %, <em>p</em> = 0.004), accompanied by a significant decrease in n-6 polyunsaturated fatty acids (−2.28 %, <em>p</em> = 0.003).</div></div><div><h3>Discussion</h3><div>This pilot study demonstrates the feasibility of conducting biomarker-based evaluations within a CM curriculum and provides preliminary biochemical evidence supporting previous self-reported findings of dietary behavior change. The study illustrates a promising approach for integrating objective outcome measures into CM education and informs the design of future, adequately powered trials.</div></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"29 ","pages":"Article 100431"},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning–based binary classification of elevated HbA1c (≥6.5 %) for risk assessment","authors":"Dler Hussein Kadir ,&nbsp;Azhin Mohammed Khudhur ,&nbsp;Hewir Abdulqadir Khidir","doi":"10.1016/j.metop.2025.100428","DOIUrl":"10.1016/j.metop.2025.100428","url":null,"abstract":"<div><h3>Objective</h3><div>One of the most important biomarkers for evaluating long-term glycemic management and estimating the risk of diabetes is glycated hemoglobin (HbA1c). Early risk assessment and intervention techniques can be improved by identifying important clinical and demographic variables. Through the integration of clinical indicators (lipid profiles, albumin, and liver enzymes) and demographic characteristics (age, gender), this study seeks to create a comprehensive HbA1c prediction model.</div></div><div><h3>Study design</h3><div>To find the most important factors, logistic regression was used to evaluate 482 cases using a stepwise selection process.</div></div><div><h3>Results</h3><div>With an area under the curve (AUC) of 0.797, the final model had strong predictive ability. Age (OR = 1.085, p &lt; 0.001), glutamate pyruvate transaminase (GPT) (OR = 1.011, p = 0.0127), high-density lipoprotein (HDL) (OR = 0.969, p = 0.017), VitaminD3 (OR = 1.023, p = 0.014), and very low-density lipoprotein (VDL) (OR = 1.016, p = 0.018) were all significant predictors.</div></div><div><h3>Conclusions</h3><div>The greatest predictor was age, which was positively correlated with elevated HbA1c levels, whereas HDL had a protective impact. The addition of VitaminD3, VDL, and GPT implies that indicators of liver and metabolic function have a major role in the variability of HbA1c. These results demonstrate how normal clinical and demographic data may be incorporated into predictive models for early diabetes risk assessment, enabling more individualized medical care and bettering patient outcomes.</div></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"29 ","pages":"Article 100428"},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145705821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breakpoint-resolved balanced t(2;12)(q35;q24.31) disrupting HNF1A in multigenerational MODY-3: Diagnostic utility of long-read genome sequencing and therapeutic impact","authors":"Pamela Rivero-García ,&nbsp;Osvaldo M. Mutchinick ,&nbsp;Eira Huerta-Ávila ,&nbsp;Ilse A. Colorado ,&nbsp;Cristy Alfonso-López ,&nbsp;Renata Rivera-Juárez ,&nbsp;Virginia Santiago-Cano ,&nbsp;Juan José Morales-Suárez ,&nbsp;Alfredo Hidalgo-Miranda ,&nbsp;Yevgeniya Svyryd","doi":"10.1016/j.metop.2025.100430","DOIUrl":"10.1016/j.metop.2025.100430","url":null,"abstract":"<div><div>Balanced translocations that interrupt <em>HNF1A</em> are seldom documented in MODY-3. We studied a three-generation family with early-onset, non-autoimmune diabetes consistent with MODY-3. Conventional karyotyping revealed a balanced reciprocal translocation, t(2; 12)(q35; q24.31). We then opted for long-read genome sequencing using ONT® PromethION™ (median coverage 22X; read N50 11.4 kb), which mapped breakpoints at chr12:120,984,209 (<em>HNF1A</em> intron 1) and chr2:218,759,723 (intergenic region). Segregation analysis revealed that the rearrangement cosegregates with diabetes across three generations (5 affected individuals; 1 carrier). Although expression assays were not performed, disruption of <em>HNF1A</em> within intron 1 is most consistent with loss-of-function and haploinsufficiency in this context. After molecular diagnosis, sulfonylureas were added to the treatment regimen of four affected relatives, resulting in favorable clinical outcomes. To our knowledge, multigenerational cosegregation of a balanced translocation directly disrupting <em>HNF1A</em> has not been previously reported. This case introduces a breakpoint-level mechanism for MODY-3 and demonstrates why long-read sequencing is crucial when a karyotype indicates a balanced rearrangement near a monogenic diabetes locus: it resolves the structure and shortens the path to a treatment decision.</div></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"29 ","pages":"Article 100430"},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First European case of Geller syndrome complicated with hypokalemic nephropathy: A case report and literature review","authors":"Efstratios Gavriilidis ,&nbsp;Christina Antoniadou ,&nbsp;Georgia Dimopoulou ,&nbsp;Evangelos Papadimitriou ,&nbsp;Stefania-Aspasia Bakola ,&nbsp;Charalampos Papagoras ,&nbsp;Panagiotis Skendros ,&nbsp;Dimitrios Tsilingiris","doi":"10.1016/j.metop.2025.100429","DOIUrl":"10.1016/j.metop.2025.100429","url":null,"abstract":"<div><div>Geller syndrome is caused by a gain-of-function mutation in the mineralocorticoid receptor (MR), rendering it prone to activation by elevated progesterone levels during pregnancy. It is characterized by gestational hypertension and hypokalemia. We describe the case of a 35-year-old primigravida, who presented at 22 weeks of gestation with severe hypokalemia and hypertension, complicated by hypokalemic nephropathy manifesting as diabetes insipidus and proteinuria. Initial potassium replacement, eplerenone administration and desmopressin were insufficient, whereas the administration of amiloride, a potassium-sparing diuretic that inhibits epithelial sodium channels (ENaC) in the distal nephron, led to complete resolution of the clinical syndrome. The patient had no further complications and delivered a healthy infant at 37 weeks. Genetic testing did not reveal known MR mutations, suggesting that other genetic variants or epigenetic changes in MR may warrant future investigation, particularly in isolated populations. To date, 17 cases of Geller syndrome have been reported in the literature including the herein presented, which is to the best of our knowledge the first documented in Europe. Genetic testing was performed in only one case, apart from the initially reported ones. Urgent delivery was required in four cases, while amiloride, the treatment of choice, was administered in only five, highlighting the importance of early recognition of the syndrome for effective management and prevention of adverse pregnancy outcomes.</div></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"29 ","pages":"Article 100429"},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional mediation analysis of systemic inflammation in the association between serum uric acid and diabetic kidney disease: Evidence from NHANES 1999–2018","authors":"Jiaying Wang ,&nbsp;Weijing Liu ,&nbsp;Jiaoyan Li ,&nbsp;Mengxiao Li ,&nbsp;Heyan Feng ,&nbsp;Shangfei Liu ,&nbsp;Yanzhe Cheng ,&nbsp;Wei Li","doi":"10.1016/j.metop.2025.100426","DOIUrl":"10.1016/j.metop.2025.100426","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate whether systemic inflammation, quantified by the Aggregate Index of Systemic Inflammation (AISI), mediates the association between uric acid (UA) and diabetic kidney disease (DKD).</div></div><div><h3>Study design</h3><div>We analyzed data from 1716 adults with diabetes in NHANES 1999–2018. We used regression to assess UA-AISI-DKD associations and mediation analysis to quantify AISI's indirect effect. A random forest model, interpreted via SHAP, predicted DKD risk.</div></div><div><h3>Results</h3><div>Each 1 mg/dL increase in UA was associated with a 14 % higher DKD risk (adjusted OR = 1.14, 95 % CI: 1.04–1.26). UA was positively associated with AISI (β = 0.0356, p = 0.0058), which in turn predicted DKD (OR = 1.25 per SD increase in ln-AISI, 95 % CI: 1.10–1.42). AISI partially mediates (10.94 %) the association between UA and DKD, indicating that systemic inflammation is one of several pathways linking hyperuricemia to renal injury. The random forest model performed best, with SHAP highlighting AISI as a key positive predictor.</div></div><div><h3>Conclusion</h3><div>Systemic inflammation, as measured by AISI, partially mediates the cross-sectional association between serum uric acid and diabetic kidney disease, supporting inflammation as one of several contributing pathways. The predictive performance of models incorporating AISI remains modest and does not outperform conventional clinical risk scores.</div></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"28 ","pages":"Article 100426"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sleep quality and glycemic variability among South Indian rural patients with Type-2 diabetes mellitus","authors":"Mohammed Azhar Hussain ,&nbsp;H. Anil Kumar ,&nbsp;Mahadevamma Lingaiah","doi":"10.1016/j.metop.2025.100427","DOIUrl":"10.1016/j.metop.2025.100427","url":null,"abstract":"<div><h3>Background</h3><div>Sleep quality plays a vital role in glucose homeostasis and may influence glycemic variability among diabetic individuals. The main objective of this study is to investigate the relationship between subjective sleep quality and glycemic variability in patients with Type-2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>Sixty-two adults with type 2 diabetes mellitus underwent Continuous Glucose Monitoring (CGM) and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Patients with at least three days of valid CGM data were included in the analyses. Glycemic variability was quantified using coefficient of variation (%CV). Spearman's correlation and multiple linear regression modelling were used to examine the association between glycemic variability (%CV) and sleep quality.</div></div><div><h3>Results</h3><div>Sleep-efficiency showed a significant positive correlation with %CV (r = 0.28, p = 0.03), whereas greater sleep disturbances were associated with lower TBR (r = −0.27, p = 0.04). A %CV threshold of 32.3 was identified as a cutoff for distinguishing stable and unstable glycemic patterns; however, this threshold is exploratory and requires further validation. In multiple linear regression analyses reduced sleep efficiency (β = 7.77, p = 0.002) was significantly associated with higher glycemic variability, while sleep medication use (β = −2.12, p = 0.01) also showed significant association after adjustment for HbA1c, microvascular and macrovascular complications.</div></div><div><h3>Conclusion</h3><div>Poor sleep quality, particularly sleep efficiency exhibited a significant relationship with glycemic variability. Improving sleep quality may represent a practical and modifiable strategy to improve glycemic stability in this population.</div></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"28 ","pages":"Article 100427"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fighting fire with fire: PLA2G15 inhibition mobilizes BMP lipids to combat NPC1 disease","authors":"Wei Meng ,&nbsp;Junli Liu ,&nbsp;Xun Huang","doi":"10.1016/j.metop.2025.100390","DOIUrl":"10.1016/j.metop.2025.100390","url":null,"abstract":"","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"28 ","pages":"Article 100390"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}