In Vitro and In Vivo Antidiabetic Effects of Acidic Polysaccharides Extracted from Seaweeds.

IF 0.7 4区医学 Q4 NUTRITION & DIETETICS Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI:10.3177/jnsv.69.98

Mihoko Moto, Akihiko Murota, Naoko Takamizawa, Asae Nakamura, Kazuyasu Iwasaki, Katsuyuki Tanaka, Kaname Katsuraya

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Abstract

We evaluated the α-glucosidase inhibitory activity of acidic polysaccharides (APs) extracted from seaweeds in vitro and their antidiabetic effects in KK-A^y mice. The α-glucosidase inhibitory activity of APs was differed among various seaweed species. Some APs showed higher inhibitory activity in the high-molecular-weight range, whereas others showed higher inhibitory activity in the low-molecular-weight range. Mice were fed low-molecular-weight APs from hijiki (LMWAPsH), which showed higher α-glucosidase inhibitory activity. Fasting blood glucose and HbA1c levels were significantly lower in the LMWAPsH group than in the control group (p<0.01). The calculated homeostasis model assessment-insulin resistance in the LMWAPsH group was significantly lower than that in the control group (p<0.05). These results suggest that α-glucosidase inhibitory activity differ among APs from different seaweed species, and each have an optimum molecular-weight range, and that LMWAPsH prevents the hyperglycemia in KK-A^y mice.

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海藻酸性多糖体内外抗糖尿病作用的研究。

研究海藻酸性多糖(APs)体外α-葡萄糖苷酶抑制活性及其对KK-Ay小鼠的抗糖尿病作用。紫菜多糖对α-葡萄糖苷酶的抑制活性在不同海藻种类间存在差异。一些APs在高分子量范围内表现出较高的抑制活性，而另一些APs在低分子量范围内表现出较高的抑制活性。小鼠喂食低分子羊栖菜ap (LMWAPsH)，显示出较高的α-葡萄糖苷酶抑制活性。LMWAPsH组的空腹血糖和HbA1c水平明显低于对照组(py小鼠)。

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来源期刊

Journal of nutritional science and vitaminology 医学-营养学

CiteScore

1.80

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Nutritional Science and Vitaminology is an international medium publishing in English of original work in all branches of nutritional science, food science and vitaminology from any country. Manuscripts submitted for publication should be as concise as possible and must be based on the results of original research or of original interpretation of existing knowledge not previously published. Although data may have been reported, in part, in preliminary or abstract form, a full report of such research is unacceptable if it has been or will be submitted for consideration by another journal.