A systematic review on the association between exposure to air particulate matter during pregnancy and the development of hypertensive disorders of pregnancy and gestational diabetes mellitus.

IF 3 4区 医学 Q2 ENVIRONMENTAL SCIENCES Reviews on Environmental Health Pub Date : 2023-05-04 DOI:10.1515/reveh-2022-0258
Daniela Alvarado-Jiménez, Gabriele Donzelli, María Morales-Suárez-Varela
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Abstract

Particulate matter (PM) is considered an intrauterine toxin that can cross the blood-placental barrier and circulate in fetal blood, affecting fetal development, and implicating placental and intrauterine inflammation, and oxidative damage. However, the relationship between PM exposure and adverse pregnancy outcomes is still unclear and our aim was to systematically review toxicological evidence on the link between PM exposure during pregnancy and the development of gestational diabetes mellitus or hypertensive disorders of pregnancy, including gestational hypertension and pre-eclampsia. PubMed and Science Direct were searched until January 2022. Of the 204 studies identified, 168 were excluded. The remaining articles were assessed in full-text, and after evaluation, 27 were included in the review. Most of the studies showed an association between PM exposure and gestational hypertension, systolic and diastolic blood pressure, pre-eclampsia, and gestational diabetes mellitus. These results should be interpreted with caution due to the heterogeneity of baseline concentrations, which ranged from 3.3 μg/m3 to 85.9 μg/m3 and from 21.8 μg/m3 to 92.2 μg/m3, respectively for PM2.5 and PM10. Moreover, critical exposure periods were not consistent among studies, with five out of ten observational studies reporting the second trimester as the critical period for hypertensive disorders of pregnancy, and ten out of twelve observational studies reporting the first or second trimester as the critical period for gestational diabetes mellitus. Overall, the findings support an association between PM exposure during pregnancy and adverse pregnancy outcomes, highlighting the need for further research to identify the critical exposure periods and underlying mechanisms.

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关于孕期接触空气颗粒物与妊娠高血压和妊娠糖尿病之间关系的系统综述。
颗粒物(PM)被认为是一种宫内毒素,可穿过血液-胎盘屏障并在胎儿血液中循环,影响胎儿发育,并与胎盘和宫内炎症及氧化损伤有关。然而,可吸入颗粒物暴露与不良妊娠结局之间的关系仍不清楚,我们的目的是系统地回顾妊娠期可吸入颗粒物暴露与妊娠糖尿病或妊娠高血压疾病(包括妊娠高血压和先兆子痫)发生之间关系的毒理学证据。对PubMed和Science Direct的检索截止到2022年1月。在已确定的 204 项研究中,有 168 项被排除。对其余文章进行了全文评估,经评估后,27 篇文章被纳入综述。大多数研究表明,接触可吸入颗粒物与妊娠高血压、收缩压和舒张压、子痫前期和妊娠糖尿病之间存在关联。PM2.5 和 PM10 的基线浓度分别为 3.3 μg/m3 至 85.9 μg/m3 和 21.8 μg/m3 至 92.2 μg/m3,因此在解释这些结果时应谨慎。此外,各研究的关键暴露期并不一致,10 项观察性研究中有 5 项报告称妊娠期高血压疾病的关键暴露期为妊娠期后三个月,12 项观察性研究中有 10 项报告称妊娠期糖尿病的关键暴露期为妊娠期前三个月或后三个月。总之,研究结果表明,孕期接触可吸入颗粒物与不良妊娠结局之间存在关联,这突出表明有必要开展进一步研究,以确定关键接触期及其内在机制。
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来源期刊
Reviews on Environmental Health
Reviews on Environmental Health Social Sciences-Health (social science)
CiteScore
7.20
自引率
2.60%
发文量
75
期刊介绍: Reviews on Environmental Health (REVEH) is an international peer-reviewed journal that aims to fill the need for publication of review articles on hot topics in the field of environmental health. Reviews on Environmental Health aims to be an inspiring forum for scientists, environmentalists, physicians, engineers, and students who are concerned with aspects of human health, including quality of life, that are determined by physiological and psychosociological interactions between man and physical, chemical, biological, and social factors in the environment. Reviews on Environmental Health is an important niche served by no other journal, that’s being a site where thoughtful reviews can be published on a variety of subjects related to both health and environment. One challenge is to bridge the research on environmental causes of disease with the clinical practice of medicine. Reviews on Environmental Health is a source of integrated information on environment and health subjects that will be of value to the broad scientific community, whether students, junior and senior professionals, or clinicians.
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