Transforming Growth Factor Β as a Marker of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C Virus Infection.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Reports of Biochemistry and Molecular Biology Pub Date : 2023-01-01 DOI:10.52547/rbmb.11.4.702

Assem Abdeen Radwan, Nour El-Dean Abd-Elazeem Hefney, Emad Farah Mohammed Kholef, Abdallah Elebidi, Hala Mahmoud

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引用次数: 1

Abstract

Background: The Transforming Growth Factor-beta (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role in hepatocarcinogenesis is controversial. To highlight the role of Transforming Growth Factor β as a marker of Hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV) infection.

Methods: Ninety subjects were enrolled in this study, classified into three groups: Group I (chronic HCV group) included 30 patients with chronic HCV infection; Group II (HCC group) include 30 patients having HCC and chronic HCV infection and Group III consisted of 30 age and sex-matched healthy controls. TGF-β was evaluated in all the enrollees and its levels were correlated to liver function and other clinical parameters.

Results: TGF-β was found significantly higher in HCC group than in control and chronic HCV (P<0.001). In addition, it was correlated with biochemical and clinical parameters of cancer.

Conclusion: Patients with HCC showed increased level of TGF-β compared to chronic HCV infection patients and controls.

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转化生长因子Β作为慢性丙型肝炎病毒感染患者肝细胞癌的标志物

背景:转化生长因子-β (TGF-β)是与肝脏纤维化或肝硬化进展相关的主要生长因子之一，但其在肝癌发生中的作用存在争议。目的探讨转化生长因子β在慢性丙型肝炎病毒(HCV)感染患者中作为肝细胞癌(HCC)标志物的作用。方法:90例受试者被纳入本研究，分为三组:第一组(慢性HCV组)30例慢性HCV感染患者;II组(HCC组)包括30例HCC合并慢性HCV感染的患者，III组包括30例年龄和性别匹配的健康对照。在所有受试者中评估TGF-β，其水平与肝功能和其他临床参数相关。结果:HCC组TGF-β水平明显高于对照组和慢性HCV组(p结论:HCC患者TGF-β水平高于慢性HCV感染患者和对照组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.