Repetitive thought, cognition, and systemic inflammation in the midlife in the United States study.

IF 1.9 3区心理学 Q2 PSYCHOLOGY, MULTIDISCIPLINARY Psychology & Health Pub Date : 2024-05-01 Epub Date: 2022-06-27 DOI:10.1080/08870446.2022.2092104

Elana M Gloger, Suzanne C Segerstrom

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Abstract

Objective: Poor cognition increases risk for negative health outcomes, and this may be explained by associations with systemic inflammation. Previously, amount of repetitive thought (Total RT) interacted with IQ to predict interleukin-6 (IL-6) in older adults. This study continued the investigation of repetitive thought (RT) as an element involved in the effect of cognition on inflammation.

Design: Participants (N = 164) came from the Midlife in the United States Refresher project (M_age = 45.33, SD = 11.51, ranges = 25-74; 48.2% female; 85% Caucasian). Cognition was assessed via telephone, inflammatory biomarkers (IL-6, C-reactive protein (CRP), and tumour-necrosis factor-alpha (TNF- α)) analysed after blood draw, and RT derived from daily diary data.

Results: Cognition significantly interacted with RT valence (p = .009) to explain CRP after covariate adjustment. Better cognition and more negative RT valence was associated with lower CRP (β = -0.190 [-.387, .008]). Worse cognition and more negative RT valence was associated with higher CRP (β = 0.133 [-.031, .297]). No significant effects were found for IL-6 or TNF-α.

Conclusion: RT may interact with cognition to affect different inflammatory biomarkers. Those with worse cognition may benefit more from skills related to regulating thought than those with better cognition.

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美国中年研究中的重复思维、认知和全身炎症。

目的认知能力差会增加不良健康后果的风险，这可能与全身炎症有关。此前，重复思维量（Total RT）与智商相互作用，可预测老年人的白细胞介素-6（IL-6）。本研究继续调查重复思维（RT）作为认知对炎症影响的一个因素：参与者（N = 164）来自美国中年进修项目（年龄 = 45.33，SD = 11.51，范围 = 25-74；48.2% 为女性；85% 为白种人）。认知能力通过电话进行评估，炎症生物标志物（IL-6、C反应蛋白（CRP）和肿瘤坏死因子-α（TNF- α））在抽血后进行分析，RT来自每日日记数据：结果：经协变量调整后，认知与RT价显著交互作用（p = .009），可解释CRP。较好的认知能力和较消极的 RT 价态与较低的 CRP 相关（β = -0.190 [-.387, .008]）。较差的认知能力和更消极的 RT 价态与较高的 CRP 相关（β = 0.133 [-.031, .297]）。IL-6和TNF-α均无明显影响：RT可能与认知能力相互作用，影响不同的炎症生物标志物。与认知能力较好的人相比，认知能力较差的人可能从与调节思维相关的技能中获益更多。

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来源期刊

Psychology & Health Multiple-

CiteScore

7.30

自引率

3.00%

发文量

期刊介绍： Psychology & Health promotes the study and application of psychological approaches to health and illness. The contents include work on psychological aspects of physical illness, treatment processes and recovery; psychosocial factors in the aetiology of physical illnesses; health attitudes and behaviour, including prevention; the individual-health care system interface particularly communication and psychologically-based interventions. The journal publishes original research, and accepts not only papers describing rigorous empirical work, including meta-analyses, but also those outlining new psychological approaches and interventions in health-related fields.