Atherosclerosis and multi-organ-associated pathologies.

IF 7.9 2区 医学 Q1 IMMUNOLOGY Seminars in Immunopathology Pub Date : 2022-05-01 DOI:10.1007/s00281-022-00914-y
W Coles Keeter, Shelby Ma, Natalie Stahr, Alina K Moriarty, Elena V Galkina
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引用次数: 11

Abstract

Atherosclerosis is a chronic inflammatory disease of the vascular system that is characterized by the deposition of modified lipoproteins, accumulation of immune cells, and formation of fibrous tissue within the vessel wall. The disease occurs in vessels throughout the body and affects the functions of almost all organs including the lymphoid system, bone marrow, heart, brain, pancreas, adipose tissue, liver, kidneys, and gastrointestinal tract. Atherosclerosis and associated factors influence these tissues via the modulation of local vascular functions, induction of cholesterol-associated pathologies, and regulation of local immune responses. In this review, we discuss how atherosclerosis interferers with functions of different organs via several common pathways and how the disturbance of immunity in atherosclerosis can result in disease-provoking dysfunctions in multiple tissues. Our growing appreciation of the implication of atherosclerosis and associated microenvironmental conditions in the multi-organ pathology promises to influence our understanding of CVD-associated disease pathologies and to provide new therapeutic opportunities.

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动脉粥样硬化和多器官相关病理。
动脉粥样硬化是血管系统的一种慢性炎症性疾病,其特征是修饰脂蛋白的沉积、免疫细胞的积累和血管壁内纤维组织的形成。这种疾病发生在全身的血管中,影响几乎所有器官的功能,包括淋巴系统、骨髓、心脏、大脑、胰腺、脂肪组织、肝脏、肾脏和胃肠道。动脉粥样硬化及其相关因素通过调节局部血管功能、诱导胆固醇相关病理和调节局部免疫反应来影响这些组织。在这篇综述中,我们讨论了动脉粥样硬化如何通过几种常见途径干扰不同器官的功能,以及动脉粥样硬化中免疫紊乱如何导致多种组织的疾病功能障碍。我们对动脉粥样硬化和相关微环境条件在多器官病理中的含义的日益认识有望影响我们对心血管疾病相关疾病病理的理解,并提供新的治疗机会。
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来源期刊
Seminars in Immunopathology
Seminars in Immunopathology 医学-病理学
CiteScore
19.80
自引率
2.20%
发文量
69
审稿时长
12 months
期刊介绍: The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.
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