Dopamine, Immunity, and Disease.

IF 19.3 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological Reviews Pub Date : 2023-01-01 DOI:10.1124/pharmrev.122.000618
Breana Channer, Stephanie M Matt, Emily A Nickoloff-Bybel, Vasiliki Pappa, Yash Agarwal, Jason Wickman, Peter J Gaskill
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引用次数: 20

Abstract

The neurotransmitter dopamine is a key factor in central nervous system (CNS) function, regulating many processes including reward, movement, and cognition. Dopamine also regulates critical functions in peripheral organs, such as blood pressure, renal activity, and intestinal motility. Beyond these functions, a growing body of evidence indicates that dopamine is an important immunoregulatory factor. Most types of immune cells express dopamine receptors and other dopaminergic proteins, and many immune cells take up, produce, store, and/or release dopamine, suggesting that dopaminergic immunomodulation is important for immune function. Targeting these pathways could be a promising avenue for the treatment of inflammation and disease, but despite increasing research in this area, data on the specific effects of dopamine on many immune cells and disease processes remain inconsistent and poorly understood. Therefore, this review integrates the current knowledge of the role of dopamine in immune cell function and inflammatory signaling across systems. We also discuss the current understanding of dopaminergic regulation of immune signaling in the CNS and peripheral tissues, highlighting the role of dopaminergic immunomodulation in diseases such as Parkinson's disease, several neuropsychiatric conditions, neurologic human immunodeficiency virus, inflammatory bowel disease, rheumatoid arthritis, and others. Careful consideration is given to the influence of experimental design on results, and we note a number of areas in need of further research. Overall, this review integrates our knowledge of dopaminergic immunology at the cellular, tissue, and disease level and prompts the development of therapeutics and strategies targeted toward ameliorating disease through dopaminergic regulation of immunity. SIGNIFICANCE STATEMENT: Canonically, dopamine is recognized as a neurotransmitter involved in the regulation of movement, cognition, and reward. However, dopamine also acts as an immune modulator in the central nervous system and periphery. This review comprehensively assesses the current knowledge of dopaminergic immunomodulation and the role of dopamine in disease pathogenesis at the cellular and tissue level. This will provide broad access to this information across fields, identify areas in need of further investigation, and drive the development of dopaminergic therapeutic strategies.

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多巴胺,免疫和疾病。
神经递质多巴胺是中枢神经系统(CNS)功能的关键因素,调节包括奖励、运动和认知在内的许多过程。多巴胺还调节外周器官的关键功能,如血压、肾活动和肠蠕动。除了这些功能,越来越多的证据表明多巴胺是一个重要的免疫调节因子。大多数类型的免疫细胞表达多巴胺受体和其他多巴胺能蛋白,许多免疫细胞吸收、产生、储存和/或释放多巴胺,这表明多巴胺能免疫调节对免疫功能很重要。靶向这些途径可能是治疗炎症和疾病的一个有希望的途径,但是尽管在这一领域的研究越来越多,关于多巴胺对许多免疫细胞和疾病过程的具体影响的数据仍然不一致,而且知之甚少。因此,本综述整合了多巴胺在免疫细胞功能和跨系统炎症信号中的作用的现有知识。我们还讨论了目前对多巴胺能调节中枢神经系统和外周组织免疫信号的理解,强调了多巴胺能免疫调节在帕金森病、几种神经精神疾病、神经性人类免疫缺陷病毒、炎症性肠病、类风湿性关节炎等疾病中的作用。仔细考虑了实验设计对结果的影响,我们注意到一些需要进一步研究的领域。总的来说,这篇综述整合了我们在细胞、组织和疾病水平上的多巴胺能免疫学知识,并促进了通过多巴胺能调节免疫来改善疾病的治疗方法和策略的发展。意义声明:通常,多巴胺被认为是一种参与运动、认知和奖励调节的神经递质。然而,多巴胺也在中枢神经系统和外周神经系统中作为免疫调节剂。本文综述了目前关于多巴胺能免疫调节的知识,以及多巴胺在细胞和组织水平上疾病发病机制中的作用。这将提供跨领域信息的广泛访问,确定需要进一步调查的领域,并推动多巴胺能治疗策略的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmacological Reviews
Pharmacological Reviews 医学-药学
CiteScore
34.70
自引率
0.50%
发文量
40
期刊介绍: Pharmacological Reviews is a highly popular and well-received journal that has a long and rich history of success. It was first published in 1949 and is currently published bimonthly online by the American Society for Pharmacology and Experimental Therapeutics. The journal is indexed or abstracted by various databases, including Biological Abstracts, BIOSIS Previews Database, Biosciences Information Service, Current Contents/Life Sciences, EMBASE/Excerpta Medica, Index Medicus, Index to Scientific Reviews, Medical Documentation Service, Reference Update, Research Alerts, Science Citation Index, and SciSearch. Pharmacological Reviews offers comprehensive reviews of new pharmacological fields and is able to stay up-to-date with published content. Overall, it is highly regarded by scholars.
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