Regulation of LTP at rat hippocampal Schaffer-CA1 in vitro by musical rhythmic magnetic fields generated by red-pink (soothing) music tracks.

IF 2.1 4区 医学 Q2 BIOLOGY International Journal of Radiation Biology Pub Date : 2023-01-01 DOI:10.1080/09553002.2022.2094022
Zijia Jin, Lei Dong, Lei Tian, Mei Zhou, Yu Zheng
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引用次数: 1

Abstract

Purpose: Music therapy, like red-pink (soothing) music, is an important treatment for neurological disorders associated with learning and memory. Magnetic fields have been proved to have a similar regulating effect. However, the effect of magnetic fields with musical rhythm generated by the combination of the two has not been confirmed. This study aimed to investigate the regulation of magnetic stimulation with music rhythm on LTP (long-term potentiation) of Schaffer-CA1.

Materials and methods: This article selected three sorts of music tracks in different frequencies (music track (1) Turkish March, music track (2) Moonlight Sonata, music track (3) Funeral March) and four sorts of pure sinusoidal tracks of four different harmonic frequency (music track (4) the frequency is 3500 Hz; music track (5) the frequency is 2500 Hz; music track (6) the frequency is 1500 Hz; music track (7) the frequency is 500 Hz). These music tracks are converted into analog signals by the external sound card and power amplifier and fed into a homemade coil that meets the demand for this frequency bandwidth. The coil can generate seven sorts of time-varying magnetic fields with musical rhythm with a mean intensity of about 2 mT. We used multi-electrode array (MEA) to record the LTP signals of Schaffer-CA1 synaptic induced by seven sorts of musical rhythmic magnetic fields and analyze the regulation of them.

Results: The musical rhythmic magnetic fields generated by track 1 and track 2 have a remarkable enhancing effect on the amplitude of fEPSPs (field excitatory postsynaptic potentials) (p < .05), and these effects intensify with the increase of frequency. Nevertheless, there is no significant enhancing effect on LTP of the rhythmic magnetic field generated by track 3 (p > .05). The sinusoidal magnetic fields generated by track 4 and track 5 have an enhancing effect on the amplitude of fEPSPs (p < .05), and the enhancement is better than track 1 and track 2. The sinusoidal magnetic fields generated by track 6 and track 7 have an inhibiting effect (p < .05).

Conclusion: We found that the enhancing effect of musical rhythmic magnetic fields generated by track 1 was the most significant. The frequency of 1500 Hz could be a turning-point frequency in the regulation of magnetic field on LTP.

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红粉色(舒缓)音乐产生的节奏磁场对大鼠海马Schaffer-CA1的LTP调控。
目的:音乐疗法,像红粉色(舒缓)音乐一样,是与学习和记忆有关的神经系统疾病的重要治疗方法。磁场已被证明具有类似的调节作用。然而,两者结合产生的具有音乐节奏的磁场的效果尚未得到证实。本研究旨在探讨音乐节奏磁刺激对Schaffer-CA1长期增强(LTP)的调节作用。材料与方法:本文选取了三种不同频率的音乐曲目(音乐曲目(1)土耳其进行曲、音乐曲目(2)月光奏鸣曲、音乐曲目(3)葬礼进行曲)和四种不同谐波频率的纯正弦曲目(音乐曲目(4),频率为3500赫兹;音乐轨道(5)频率为2500hz;音乐轨道(6)频率为1500hz;音乐轨道(7)的频率是500赫兹)。这些音乐轨道被外部声卡和功率放大器转换成模拟信号,并馈送到满足该频率带宽需求的自制线圈中。该线圈可产生7种具有音乐节奏的时变磁场,平均强度约为2 mT。用多电极阵列(MEA)记录了7种音乐节奏磁场诱导的Schaffer-CA1突触LTP信号,并分析了它们的调控作用。结果:音轨1和音轨2产生的音乐节奏磁场对大鼠场兴奋性突触后电位(fEPSPs)振幅有显著的增强作用(p p > 0.05)。声道4和声道5产生的正弦磁场对fEPSPs的振幅有增强作用(p p)。结论:我们发现声道1产生的音乐节奏磁场对fEPSPs的增强作用最为显著。1500 Hz的频率可以作为磁场对LTP调节的转折点频率。
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来源期刊
CiteScore
5.00
自引率
11.50%
发文量
142
审稿时长
3 months
期刊介绍: The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.
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