Efficacy of Cetylpyridinium Chloride mouthwash against SARS-CoV-2: A systematic review of randomized controlled trials.

IF 2.8 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Molecular Oral Microbiology Pub Date : 2023-06-01 DOI:10.1111/omi.12408

Filippo D'Amico, Matteo Moro, Marco Saracino, Marilena Marmiere, Maria Bernadette Cilona, Graham Lloyd-Jones, Alberto Zangrillo

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引用次数: 4

Abstract

Introduction: COVID-19 is a transmissible respiratory and multisystem disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Viral transmission occurs mainly through the spread of salivary droplets or aerosol from an infected subject. Studies suggest that salivary viral load is correlated with disease severity and probability of transmission. Cetylpyridinium chloride mouthwash has been found to be effective in reducing salivary viral load. The aim of this systematic review of randomized controlled trials is to evaluate the efficacy of the mouthwash ingredient cetylpyridinium chloride on salivary viral load in SARS-CoV-2 infection.

Methods: Randomized controlled trials comparing cetylpyridinium chloride mouthwash with placebo and other mouthwash ingredients in SARS-CoV-2 positive individuals were identified and evaluated.

Results: Six studies with a total of 301 patients that met the inclusion criteria were included. The studies reported the efficacy of cetylpyridinium chloride mouthwashes in reduction on SARS-CoV-2 salivary viral load compared to placebo and other mouthwash ingredients.

Conclusion: Mouthwashes containing cetylpyridinium chloride are effective against salivary viral load of SARS-CoV-2 in vivo. There is also the possibility that the use of mouthwash containing cetylpyridinium chloride in SARS-CoV-2 positive subjects could reduce transmissibility and severity of COVID-19.

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氯化十六烷基吡啶漱口水对SARS-CoV-2的疗效:随机对照试验的系统评价。

简介:COVID-19是由严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)引起的一种传染性呼吸系统多系统疾病。病毒主要通过受感染者的唾液飞沫或气溶胶传播。研究表明，唾液病毒载量与疾病严重程度和传播概率相关。十六烷基吡啶氯化漱口水已被发现是有效的减少唾液病毒载量。本系统综述随机对照试验的目的是评估漱口水成分氯化十六烷基吡啶对SARS-CoV-2感染患者唾液病毒载量的疗效。方法:在SARS-CoV-2阳性人群中进行随机对照试验，比较十六烷基吡啶氯化漱口水与安慰剂和其他漱口水成分。结果:6项研究共纳入301例符合纳入标准的患者。这些研究报告了与安慰剂和其他漱口水成分相比，十六烷基吡啶氯化漱口水在减少SARS-CoV-2唾液病毒载量方面的功效。结论:含十六烷基吡啶氯漱口水对体内SARS-CoV-2唾液病毒载量有较好的抑制作用。还有一种可能性是，在SARS-CoV-2阳性受试者中使用含有十六烷基氯化吡啶的漱口水可以降低COVID-19的传播性和严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Oral Microbiology DENTISTRY, ORAL SURGERY & MEDICINE-MICROBIOLOGY

CiteScore

6.50

自引率

5.40%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Oral Microbiology publishes high quality research papers and reviews on fundamental or applied molecular studies of microorganisms of the oral cavity and respiratory tract, host-microbe interactions, cellular microbiology, molecular ecology, and immunological studies of oral and respiratory tract infections. Papers describing work in virology, or in immunology unrelated to microbial colonization or infection, will not be acceptable. Studies of the prevalence of organisms or of antimicrobials agents also are not within the scope of the journal. The journal does not publish Short Communications or Letters to the Editor. Molecular Oral Microbiology is published bimonthly.