Molecular mechanisms of ferroptosis and their role in inflammation.

IF 4.3 4区 医学 Q2 IMMUNOLOGY International Reviews of Immunology Pub Date : 2023-01-01 DOI:10.1080/08830185.2021.2016739
Feng Wang, Jingya He, Ruxiao Xing, Tong Sha, Bin Sun
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引用次数: 15

Abstract

Ferroptosis is a type of non-apoptotic cell death, which demonstrates a definite iron-dependent expression pattern and is associated with lipid peroxidation. Glutathione peroxidase 4 (GPX4) is a key regulator of ferroptosis. Ferroptosis is involved in the development and progression of various diseases, such as cancer, tissue ischemia-reperfusion injury, neurological diseases, and respiratory diseases. It has been established previously that ferroptotic cells trigger the innate immune system by releasing inflammation-linked damage-related molecules, and immune cells stimulate the inflammatory response by recognizing the operational mechanism of ferroptosis. Some anti-inflammatory drugs have been shown to inhibit ferroptosis in certain cell models. Conversely, some ferroptosis inhibitors also exert anti-inflammatory effects in certain diseases. The present review evaluated the relationship between ferroptosis and inflammation, as well as the underlying internal mechanism, and provided valuable insights into developing novel treatment strategies for inflammatory diseases and cancer.

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铁下垂的分子机制及其在炎症中的作用。
铁下垂是一种非凋亡性细胞死亡,表现出明确的铁依赖性表达模式,并与脂质过氧化有关。谷胱甘肽过氧化物酶4 (gtathione peroxidase 4, GPX4)是铁下垂的关键调控因子。铁下垂参与多种疾病的发生和发展,如癌症、组织缺血-再灌注损伤、神经系统疾病和呼吸系统疾病。先前已经确定,铁下垂细胞通过释放炎症相关损伤相关分子触发先天免疫系统,免疫细胞通过识别铁下垂的运作机制刺激炎症反应。一些抗炎药物在某些细胞模型中显示出抑制铁下垂的作用。相反,一些铁下垂抑制剂在某些疾病中也有抗炎作用。本文综述了铁下垂与炎症之间的关系及其潜在的内在机制,为开发炎症性疾病和癌症的新治疗策略提供了宝贵的见解。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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