Increased Risk of Glaucoma in Patients with Sjögren's Syndrome: A Nationwide Population-Based Cohort Study.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY Ophthalmic epidemiology Pub Date : 2024-04-01 Epub Date: 2023-05-14 DOI:10.1080/09286586.2023.2213766

Bingsian Lin, Chi-Hsiang Chung, Chien-An Sun, Ching-Long Chen, Wu-Chien Chien

{"title":"Increased Risk of Glaucoma in Patients with Sjögren's Syndrome: A Nationwide Population-Based Cohort Study.","authors":"Bingsian Lin, Chi-Hsiang Chung, Chien-An Sun, Ching-Long Chen, Wu-Chien Chien","doi":"10.1080/09286586.2023.2213766","DOIUrl":null,"url":null,"abstract":"Purpose: The risk of glaucoma in patients suffering from Sjögren's syndrome has not been elucidated. We aimed for evaluating the absolute incidence as well as the relative risk of glaucoma in patients with SS at the level of the whole country population.Methods: We conducted a retrospective cohort study using a national health insurance database in Taiwan from 2000 to 2013. We used International Classification of Diseases, Ninth Revision, to categorise medical conditions for study group and comparison group. We used Cox proportional hazard regression analysis to determine adjusted hazard ratios (aHRs) of glaucoma between study and comparison group after adjusting for sex, age, and comorbidities.Results: Among 17,398 patients with primary Sjögren's syndrome, 133 patients were diagnosis with glaucoma during follow-up. Of the 69,592 non-primary Sjögren's syndrome patients, 429 patients developed glaucoma. Glaucoma risk was elevated in patients with primary Sjögren's syndrome than in the non-Sjögren's syndrome group (adjusted hazard ratio [HR] 2.274, 95% in the confidence interval [95% CI] 1.847-2.800; P < .001).Conclusions: The risk of glaucoma among the population having Sjögren's syndrome was higher than those did not have Sjögren's syndrome. It indicated the necessity of regular examination for glaucoma in patients with Sjögren's syndrome.","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic epidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09286586.2023.2213766","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/5/14 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The risk of glaucoma in patients suffering from Sjögren's syndrome has not been elucidated. We aimed for evaluating the absolute incidence as well as the relative risk of glaucoma in patients with SS at the level of the whole country population.

Methods: We conducted a retrospective cohort study using a national health insurance database in Taiwan from 2000 to 2013. We used International Classification of Diseases, Ninth Revision, to categorise medical conditions for study group and comparison group. We used Cox proportional hazard regression analysis to determine adjusted hazard ratios (aHRs) of glaucoma between study and comparison group after adjusting for sex, age, and comorbidities.

Results: Among 17,398 patients with primary Sjögren's syndrome, 133 patients were diagnosis with glaucoma during follow-up. Of the 69,592 non-primary Sjögren's syndrome patients, 429 patients developed glaucoma. Glaucoma risk was elevated in patients with primary Sjögren's syndrome than in the non-Sjögren's syndrome group (adjusted hazard ratio [HR] 2.274, 95% in the confidence interval [95% CI] 1.847-2.800; P < .001).

Conclusions: The risk of glaucoma among the population having Sjögren's syndrome was higher than those did not have Sjögren's syndrome. It indicated the necessity of regular examination for glaucoma in patients with Sjögren's syndrome.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

斯约格伦综合征患者罹患青光眼的风险增加：一项基于全国人口的队列研究。

目的：斯约格伦综合征患者罹患青光眼的风险尚未明确。我们的目的是在全国范围内评估斯氏综合征患者青光眼的绝对发病率和相对风险：我们使用台湾 2000 年至 2013 年的全国健康保险数据库进行了一项回顾性队列研究。我们使用国际疾病分类第九版对研究组和对比组的医疗条件进行了分类。在对性别、年龄和合并症进行调整后，我们使用 Cox 比例危险回归分析来确定研究组和对比组之间的调整后青光眼危险比（aHRs）：在 17,398 名原发性斯约格伦综合征患者中，有 133 名患者在随访期间被诊断出患有青光眼。在 69,592 名非原发性斯约格伦综合征患者中，有 429 名患者罹患青光眼。原发性斯约格伦氏综合征患者患青光眼的风险高于非斯约格伦氏综合征组（调整后危险比 [HR] 2.274，95% 置信区间 [95% CI] 1.847-2.800；P 结论：原发性斯约格伦氏综合征患者患青光眼的风险高于非斯约格伦氏综合征组：患有斯约格伦综合征的人群患青光眼的风险高于未患斯约格伦综合征的人群。这表明有必要对斯约格伦综合征患者进行定期青光眼检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Ophthalmic epidemiology 医学-眼科学

CiteScore

3.70

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.