Antibody engineering and its therapeutic applications.

IF 4.3 4区 医学 Q2 IMMUNOLOGY International Reviews of Immunology Pub Date : 2023-01-01 DOI:10.1080/08830185.2021.1960986
Divya Kandari, Rakesh Bhatnagar
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引用次数: 5

Abstract

As a natural function, antibodies defend the host from infected cells and pathogens by recognizing their pathogenic determinants. Antibodies (Abs) gained wide acceptance with an enormous impact on human health and have predominantly captured the arena of bio-therapeutics and bio-diagnostics. The scope of Ab-based biologics is vast, and it is likely to solve many unmet clinical needs in future. The majority of attention is now devoted to developing innovative technologies for manufacturing and engineering Abs, better suited to satisfy human needs. The advent of Ab engineering technologies (AET) led to phenomenal developments leading to the generation of Abs-/Ab-derived molecules with desirable functional properties proportional to their expanding requirements. Evolution brought by AET, from the naturally occurring Ab forms to several advanced Ab formats and derivatives, was much needed as it is of great interest to the pharmaceutical industry. Thus, numerous advancements in AET have propelled success in therapeutic Ab development, along with the potential for ever-increasing improvements. Unique characteristics of Abs, such as its diversity, specificity, structural integrity and an array of possible applications, together inspire continuous innovation in the field. Overall, the AET could assist in conquer of several limitations of Abs in terms of their applicability in the field of therapeutics, diagnostics and research; AET has so far led to the production of next-generation Abs, which have revolutionized these arenas. Here in this review, we discuss the various distinguished engineering platforms for Ab development and the progress in modern therapeutics by the so-called "next-generation Abs."

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抗体工程及其治疗应用。
作为一种自然功能,抗体通过识别其致病决定因素来保护宿主免受感染细胞和病原体的侵害。抗体(Abs)因其对人类健康的巨大影响而获得广泛接受,并已在生物治疗和生物诊断领域占据主导地位。基于抗体的生物制剂的应用范围是广阔的,未来很可能解决许多未满足的临床需求。现在,大多数注意力都集中在开发制造和工程Abs的创新技术上,以更好地满足人类的需求。抗体工程技术(AET)的出现导致了惊人的发展,导致产生具有理想功能特性的抗体/抗体衍生分子与其扩展需求成正比。AET带来的进化,从自然存在的Ab形式到几种高级Ab形式和衍生物,是非常需要的,因为它对制药工业非常感兴趣。因此,AET的许多进步推动了治疗性Ab开发的成功,以及不断增加的改进潜力。Abs的独特特性,如其多样性、特异性、结构完整性和一系列可能的应用,共同激发了该领域的不断创新。总的来说,AET可以帮助克服抗体在治疗、诊断和研究领域的适用性方面的几个局限性;到目前为止,AET已经导致了下一代抗体的生产,这已经彻底改变了这些领域。在这篇综述中,我们讨论了各种杰出的抗体开发工程平台以及所谓的“下一代抗体”在现代治疗学中的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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