The role of sialic acid-binding immunoglobulin-like-lectin-1 (siglec-1) in immunology and infectious disease.

IF 4.3 4区 医学 Q2 IMMUNOLOGY International Reviews of Immunology Pub Date : 2023-01-01 DOI:10.1080/08830185.2021.1931171
Shane Prenzler, Santosh Rudrawar, Mario Waespy, Sørge Kelm, Shailendra Anoopkumar-Dukie, Thomas Haselhorst
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引用次数: 5

Abstract

Siglec-1, also known as Sialoadhesin (Sn) and CD169 is highly conserved among vertebrates and with 17 immunoglobulin-like domains is Siglec-1 the largest member of the Siglec family. Expression of Siglec-1 is found primarily on dendritic cells (DCs), macrophages and interferon induced monocyte. The structure of Siglec-1 is unique among siglecs and its function as a receptor is also different compared to other receptors in this class as it contains the most extracellular domains out of all the siglecs. However, the ability of Siglec-1 to internalize antigens and to pass them on to lymphocytes by allowing dendritic cells and macrophages to act as antigen presenting cells, is the main reason that has granted Siglec-1's key role in multiple human disease states including atherosclerosis, coronary artery disease, autoimmune diseases, cell-cell signaling, immunology, and more importantly bacterial and viral infections. Enveloped viruses for example have been shown to manipulate Siglec-1 to increase their virulence by binding to sialic acids present on the virus glycoproteins allowing them to spread or evade immune response. Siglec-1 mediates dissemination of HIV-1 in activated tissues enhancing viral spread via infection of DC/T-cell synapses. Overall, the ability of Siglec-1 to bind a variety of target cells within the immune system such as erythrocytes, B-cells, CD8+ granulocytes and NK cells, highlights that Siglec-1 is a unique player in these essential processes.

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唾液酸结合免疫球蛋白样凝集素-1 (siglec1)在免疫学和感染性疾病中的作用。
siglec1,也被称为唾液粘附素(Sn)和CD169,在脊椎动物中高度保守,具有17个免疫球蛋白样结构域,是siglec1家族中最大的成员。siglec1主要在树突状细胞、巨噬细胞和干扰素诱导的单核细胞中表达。siglec1的结构在siglecs中是独一无二的,它作为受体的功能也与同类其他受体不同,因为它在所有siglecs中包含最多的细胞外结构域。然而,siglec1内化抗原并通过允许树突状细胞和巨噬细胞作为抗原呈递细胞将抗原传递到淋巴细胞的能力,是siglec1在多种人类疾病状态中发挥关键作用的主要原因,包括动脉粥样硬化、冠状动脉疾病、自身免疫性疾病、细胞-细胞信号传导、免疫学,更重要的是细菌和病毒感染。例如,包膜病毒已被证明通过与病毒糖蛋白上存在的唾液酸结合来操纵siglec1以增加其毒力,从而使其传播或逃避免疫反应。siglec1介导HIV-1在活化组织中的传播,通过感染DC/ t细胞突触增强病毒传播。总之,siglec1结合免疫系统内多种靶细胞的能力,如红细胞、b细胞、CD8+粒细胞和NK细胞,突出表明siglec1在这些重要过程中是一个独特的参与者。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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