Microbial sensing in the intestine.

IF 13.6 1区 生物学 Q1 CELL BIOLOGY Protein & Cell Pub Date : 2023-11-08 DOI:10.1093/procel/pwad028
Tingting Wan, Yalong Wang, Kaixin He, Shu Zhu
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Abstract

The gut microbiota plays a key role in host health and disease, particularly through their interactions with the immune system. Intestinal homeostasis is dependent on the symbiotic relationships between the host and the diverse gut microbiota, which is influenced by the highly co-evolved immune-microbiota interactions. The first step of the interaction between the host and the gut microbiota is the sensing of the gut microbes by the host immune system. In this review, we describe the cells of the host immune system and the proteins that sense the components and metabolites of the gut microbes. We further highlight the essential roles of pattern recognition receptors (PRRs), the G protein-coupled receptors (GPCRs), aryl hydrocarbon receptor (AHR) and the nuclear receptors expressed in the intestinal epithelial cells (IECs) and the intestine-resident immune cells. We also discuss the mechanisms by which the disruption of microbial sensing because of genetic or environmental factors causes human diseases such as the inflammatory bowel disease (IBD).

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肠道微生物感应。
肠道菌群在宿主健康和疾病中起着关键作用,特别是通过它们与免疫系统的相互作用。肠道内稳态依赖于宿主与多种肠道微生物群之间的共生关系,这种关系受到高度共同进化的免疫-微生物群相互作用的影响。宿主与肠道微生物群相互作用的第一步是宿主免疫系统对肠道微生物的感知。在这篇综述中,我们描述了宿主免疫系统的细胞和感知肠道微生物成分和代谢物的蛋白质。我们进一步强调了模式识别受体(PRRs)、G蛋白偶联受体(gpcr)、芳烃受体(AHR)和核受体在肠上皮细胞(IECs)和肠道常驻免疫细胞中表达的重要作用。我们还讨论了由于遗传或环境因素导致的微生物感知破坏导致人类疾病(如炎症性肠病(IBD))的机制。
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来源期刊
Protein & Cell
Protein & Cell CELL BIOLOGY-
CiteScore
24.00
自引率
0.90%
发文量
1029
审稿时长
6-12 weeks
期刊介绍: Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.
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