Roles of long noncoding RNAs and small extracellular vesicle-long noncoding RNAs in type 2 diabetes.

IF 3.6 3区生物学 Q3 CELL BIOLOGY Traffic Pub Date : 2022-11-01 DOI:10.1111/tra.12868

Wenguang Chang, Man Wang, Yuan Zhang, Fei Yu, Bin Hu, Katarzyna Goljanek-Whysall, Peifeng Li

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引用次数: 5

Abstract

The prevalence of a high-energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The pathological mechanism of this disease is not fully clear. Accumulated evidence has shown that noncoding RNAs have an essential regulatory role in the progression of diabetes and its complications. The roles of small noncoding RNAs, such as miRNAs, in T2D, have been extensively investigated, while the function of long noncoding RNAs (lncRNAs) in T2D has been unstudied. It has been reported that lncRNAs in T2D play roles in the regulation of pancreatic function, peripheral glucose homeostasis and vascular inflammation. In addition, lncRNAs carried by small extracellular vesicles (sEV) were shown to mediate communication between organs and participate in diabetes progression. Some sEV lncRNAs derived from stem cells are being developed as potential therapeutic agents for diabetic complications. In this review, we summarize the current knowledge relating to lncRNA biogenesis, the mechanisms of lncRNA sorting into sEV and the regulatory roles of lncRNAs and sEV lncRNAs in diabetes. Knowledge of lncRNAs and sEV lncRNAs in diabetes will aid in the development of new therapeutic drugs for T2D in the future.

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长非编码rna和细胞外小泡长非编码rna在2型糖尿病中的作用。

高能量饮食和久坐不动的生活方式增加了2型糖尿病(T2D)的发病率。T2D是一种以外周血组织高血糖和胰岛素抵抗为特征的慢性疾病。本病的病理机制尚不完全清楚。越来越多的证据表明，非编码rna在糖尿病及其并发症的进展中具有重要的调节作用。小非编码rna(如mirna)在T2D中的作用已被广泛研究，而长非编码rna (lncRNAs)在T2D中的功能尚未研究。据报道，T2D中的lncrna在胰腺功能、外周葡萄糖稳态和血管炎症的调节中发挥作用。此外，小细胞外囊泡(sEV)携带的lncRNAs被证明可以介导器官间的通讯并参与糖尿病的进展。一些来自干细胞的sEV lncrna正被开发为糖尿病并发症的潜在治疗剂。本文就lncRNA的生物学发生、lncRNA向sEV分选的机制以及lncRNA和sEV lncRNA在糖尿病中的调控作用进行综述。了解糖尿病中的lncrna和sEV lncrna将有助于未来开发新的T2D治疗药物。

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来源期刊

Traffic 生物-细胞生物学

CiteScore

8.10

自引率

2.20%

发文量

审稿时长

2 months

期刊介绍： Traffic encourages and facilitates the publication of papers in any field relating to intracellular transport in health and disease. Traffic papers span disciplines such as developmental biology, neuroscience, innate and adaptive immunity, epithelial cell biology, intracellular pathogens and host-pathogen interactions, among others using any eukaryotic model system. Areas of particular interest include protein, nucleic acid and lipid traffic, molecular motors, intracellular pathogens, intracellular proteolysis, nuclear import and export, cytokinesis and the cell cycle, the interface between signaling and trafficking or localization, protein translocation, the cell biology of adaptive an innate immunity, organelle biogenesis, metabolism, cell polarity and organization, and organelle movement. All aspects of the structural, molecular biology, biochemistry, genetics, morphology, intracellular signaling and relationship to hereditary or infectious diseases will be covered. Manuscripts must provide a clear conceptual or mechanistic advance. The editors will reject papers that require major changes, including addition of significant experimental data or other significant revision. Traffic will consider manuscripts of any length, but encourages authors to limit their papers to 16 typeset pages or less.