Does perivascular fibrin glue application have a preventive effect for the endothelial damage on saphenous vein graft? An experimental model.

IF 0.5 4区医学 Q4 SURGERY Cirugia Y Cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.22000142

Serdar Badem, Nail Kahraman, Ezgi Isil-Turhan, Temmuz Taner, Deniz Demir, Didem Melis-Oztas, Murat Ugurlucan

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Abstract

Background: The effect of tissue adhesives on coronary grafts in cardiac surgery is a controversial issue.

Objective: The aim of this study is to investigate the effect of fibrin glue (FG) applied around the saphenous vein grafts (SVG) in preventing cellular damage resulting from intraluminal pressure increase.

Methods: Twenty volunteer patients were included in this ex vivo study. The SVGs remained after coronary artery bypass grafting were connected to the arterial line of the cardiopulmonary bypass circuit. The grafts were divided into two segments and one segment received perivascular FG applied whereas the other part was used plain. SVGs were kept in circulation at 120 mmHg pressure 250 mL/min flow rate for 60 min. The tissues were sent for histopathological examination to determine the endothelial damage.

Results: Endothelial damage was more pronounced in the control group when compared with the FG group. In the FG group, no damage was seen in 13 samples and no Type 3 endothelial damage was observe whereas Type 1 injury was detected in seven specimens, Type 2 injury was observed in seven specimens, and Type 3 injury was detected in two specimens in the control group.

Conclusion: Perivascular application of FG on the SVG showed a protective effect against endothelial damage resulting from increased intraluminal pressure.

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血管周围纤维蛋白胶对大隐静脉移植内皮损伤有预防作用吗?实验模型。

背景:组织粘接剂对心脏手术冠状动脉移植的影响是一个有争议的问题。目的:探讨纤维蛋白胶(FG)在隐静脉移植物(SVG)周围的应用对预防腔内压力升高引起的细胞损伤的作用。方法:20例自愿接受体外实验的患者。冠状动脉旁路移植术后的svg与体外循环的动脉线相连。将移植物分为两段，一段血管周围灌注FG，另一段血管周围灌注FG。将svg在120 mmHg压力250 mL/min流速下循环60 min。送组织进行组织病理学检查，以确定内皮损伤情况。结果:与FG组相比，对照组内皮损伤更明显。FG组13例未见损伤，未见3型内皮损伤，对照组1型损伤7例，2型损伤7例，3型损伤2例。结论:FG在SVG血管周围应用，对腔内压力升高引起的内皮损伤具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cirugia Y Cirujanos 医学-外科

CiteScore

0.90

自引率

20.00%

发文量

207

审稿时长

6-12 weeks

期刊介绍： Cirugía y Cirujanoses exponente del desarrollo académico, científico, médico, quirúrgico y tecnológico en materia de salud en México y en el ámbito internacional. Es una revista bimestral, open access, revisada por pares, que publica en español y en inglés (traducido sin coste para los autores) artículos científicos originales, casos clínicos, artículos de revisión de interés general y cartas al editor. Los artículos se seleccionan y publican siguiendo un riguroso análisis, de acuerdo con los estándares internacionalmente aceptados. Sus espacios están abiertos a los académicos, así como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos.