Peritoneal carcinomatosis index and overall survival in patients taken to cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy.

IF 0.5 4区医学 Q4 SURGERY Cirugia Y Cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.22000272

Horacio N López-Basave, Flavia Morales-Vázquez, Ángel Herrera-Gómez, Gerardo Miranda-Devora, Alejandro E Padilla-Rosciano, Carolina Castillo-Morales, César A Paleta-Torres, Ezequiel Vázquez-Cortes

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Abstract

Background: The peritoneal carcinomatosis (PC) secondary to gastrointestinal or gynecological cancer has increased its incidence. It has a worse prognosis compared to other sites of metastasis. The peritoneal carcinomatosis index (PCI) establishes overall survival in patients with gastrointestinal or gynecological tumors and carcinomatosis.

Objective: To evaluate the relationship of PCI to overall survival (OS) and recurrence-free survival (RFS) in patients treated with cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC).

Method: A descriptive, retrolective study of 80 charts of patients with CP was conducted. We included patients with colon, ovarian, appendicular, pseudomyxoma and gastric tumors with CP treated with CRS plus HIPEC. The OS and RFS were determined according to the type of adenocarcinoma and the degree of differentiation. The OS and RFS were determined in months in patients with PCI > 15 PCI as well as in patients with PCI < 15 considering the tumor of origin.

Results: Patients with ovarian tumors and pseudomyxoma with PCI < 15 presented OS > 70 months, compared to patients with gastric tumors (4 months).

Conclusions: The PCI and histology are predictors of OS. Patients with ovarian tumors and PCI < 15 have higher OS, similar to pseudomyxomas. RFS was also higher in patients with PCI < 15.

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行细胞减缩手术加腹腔热化疗的腹膜癌指数和总生存率。

背景:继发于胃肠道或妇科肿瘤的腹膜癌(PC)发病率增高。与其他转移部位相比，它的预后较差。腹膜癌指数(PCI)确定了胃肠道或妇科肿瘤和癌病患者的总生存率。目的:探讨PCI与细胞减少手术(CRS)联合腹腔热疗(HIPEC)患者总生存期(OS)和无复发生存期(RFS)的关系。方法:对80例CP患者的病历进行描述性、回顾性研究。我们纳入了结肠、卵巢、阑尾、假性黏液瘤和胃肿瘤的CP患者，并采用CRS + HIPEC治疗。根据腺癌的类型和分化程度确定OS和RFS。考虑肿瘤来源，以月为单位确定PCI > 15 PCI患者和PCI < 15患者的OS和RFS。结果:PCI < 15的卵巢肿瘤及假性粘液瘤患者OS > 70个月，而胃肿瘤患者OS为4个月。结论:PCI和组织学是OS的预测因素。卵巢肿瘤且PCI < 15的患者OS较高，与假性黏液瘤相似。PCI < 15的患者RFS也更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cirugia Y Cirujanos 医学-外科

CiteScore

0.90

自引率

20.00%

发文量

207

审稿时长

6-12 weeks

期刊介绍： Cirugía y Cirujanoses exponente del desarrollo académico, científico, médico, quirúrgico y tecnológico en materia de salud en México y en el ámbito internacional. Es una revista bimestral, open access, revisada por pares, que publica en español y en inglés (traducido sin coste para los autores) artículos científicos originales, casos clínicos, artículos de revisión de interés general y cartas al editor. Los artículos se seleccionan y publican siguiendo un riguroso análisis, de acuerdo con los estándares internacionalmente aceptados. Sus espacios están abiertos a los académicos, así como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos.