Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations.

IF 4.8 Q1 GENETICS & HEREDITY Environmental Epigenetics Pub Date : 2022-01-01 DOI:10.1093/eep/dvac017
Laurie K Svoboda, Tomoko Ishikawa, Dana C Dolinoy
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引用次数: 2

Abstract

Despite substantial strides in diagnosis and treatment, cardiovascular diseases (CVDs) continue to represent the leading cause of death in the USA and around the world, resulting in significant morbidity and loss of productive years of life. It is increasingly evident that environmental exposures during early development can influence CVD risk across the life course. CVDs exhibit marked sexual dimorphism, but how sex interacts with environmental exposures to affect cardiovascular health is a critical and understudied area of environmental health. Emerging evidence suggests that developmental exposures may have multi- and transgenerational effects on cardiovascular health, with potential sex differences; however, further research in this important area is urgently needed. Lead (Pb), phthalate plasticizers, and perfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants with numerous adverse human health effects. Notably, recent evidence suggests that developmental exposure to each of these toxicants has sex-specific effects on cardiovascular outcomes, but the underlying mechanisms, and their effects on future generations, require further investigation. This review article will highlight the role for the developmental environment in influencing cardiovascular health across generations, with a particular emphasis on sex differences and epigenetic mechanisms. In particular, we will focus on the current evidence for adverse multi and transgenerational effects of developmental exposures to Pb, phthalates, and PFAS and highlight areas where further research is needed.

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发育毒物暴露和跨代表观遗传程序和心血管健康的性别特异性影响。
尽管在诊断和治疗方面取得了长足的进步,但心血管疾病(cvd)仍然是美国和世界各地的主要死亡原因,导致严重的发病率和生产性生命年的损失。越来越明显的是,早期发育期间的环境暴露会影响整个生命过程中心血管疾病的风险。心血管疾病表现出明显的性别二态性,但性别如何与环境暴露相互作用以影响心血管健康是环境健康的一个关键且研究不足的领域。新出现的证据表明,发育暴露可能对心血管健康具有多代和跨代影响,并存在潜在的性别差异;然而,在这一重要领域的进一步研究是迫切需要的。铅(Pb)、邻苯二甲酸酯增塑剂和全氟烷基物质(PFAS)是普遍存在的环境污染物,对人类健康有许多不利影响。值得注意的是,最近的证据表明,在发育过程中暴露于这些毒物中的每一种对心血管结果都有性别特异性的影响,但潜在的机制及其对后代的影响需要进一步研究。这篇综述文章将强调发育环境在影响心血管健康的跨代作用,特别强调性别差异和表观遗传机制。我们将特别关注目前关于发育暴露于铅、邻苯二甲酸盐和PFAS的不利多代和跨代影响的证据,并强调需要进一步研究的领域。
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来源期刊
Environmental Epigenetics
Environmental Epigenetics GENETICS & HEREDITY-
CiteScore
6.50
自引率
5.30%
发文量
0
审稿时长
17 weeks
期刊最新文献
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