Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE): Case report of a 63-year-old male patient with a rare self-healing oral mucosal lesion

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-10-01 DOI:10.1016/j.jormas.2023.101514

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Abstract

Traumatic Ulcerative Granuloma with Stromal Eosinophilia (TUGSE)/Riga Fede disease is a rare mucosal and submucosal benign reactive inflammatory process, usually involving the tongue.

Trauma is believed to be a major factor amongst the multiple pathogenic mechanisms that have been hypothesized in TUGSE. The lesion presents as an isolated indurated or even ulcerated mass, which may mimic, clinically a squamous cell carcinoma (SCC).

We herein report a case of TUGSE in a 63-year-old male referred by his treating physician for high suspicion of tongue malignancy. Histopathological examination confirmed the diagnosis of TUGSE, without any evidence of a neoplasic, infectious or hematologic process.

TUGSE occurs in patients with an age range of 41–60 years. Sufficiently deep biopsies with comprehensive immunohistochemical and molecular analyses are mandatory to confirm the benign nature of the lesion and to, definitely, rule out malignancy.

This report highlights the need for adequate histological differential diagnosis to avoid inappropriate heavy treatments in a benign condition.

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外伤性溃疡性肉芽肿伴基质嗜酸性粒细胞增多症（TUGSE）：一例63岁男性患者罕见的自愈性口腔粘膜病变的病例报告。

外伤性溃疡性肉芽肿伴间质嗜酸性粒细胞增多症（TUGSE）/里加-费德病是一种罕见的粘膜和粘膜下良性反应性炎症过程，通常累及舌头。创伤被认为是TUGSE中假设的多种致病机制中的一个主要因素。病变表现为孤立的硬结甚至溃疡性肿块，临床上可能模拟鳞状细胞癌（SCC）。我们在此报告一位63岁男性因高度怀疑舌头恶性肿瘤而转诊的TUGSE病例。组织病理学检查证实了TUGSE的诊断，没有任何肿瘤、感染或血液学过程的证据。TUGSE发生在41-60岁的患者中。必须进行足够深入的活检，并进行全面的免疫组织化学和分子分析，以确认病变的良性性质，并明确排除恶性肿瘤。这份报告强调了对良性疾病进行充分的组织学鉴别诊断的必要性，以避免不适当的重型治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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